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Moumoujus

LUFFA OPERCULATA EXTRACT.

Questionable CAS 90063-68-6 / SKIN CONDITIONING

Luffa Operculata Extract, derived from the sponge gourd, is noted for its antimicrobial and antioxidant properties. While preclinical studies show promise for its biological activities, human clinical data specifically for topical skin application of the isolated extract remains limited, with significant safety considerations.

Summary

Skin conditioning Antimicrobial Antioxidant

Science

Mechanism of Action

This extract operates via a spectrum of phytochemicals including flavonoids, saponins, free steroids, and phenolic acids. It demonstrates antimicrobial capabilities against various bacteria, such as *Streptococcus pyogenes* and *Staphylococcus aureus*, and the yeast *Candida albicans*, partly attributed to 2,3-dicaffeoylglycaric acid. Furthermore, its antioxidant components actively protect the skin by neutralizing free radicals, thereby mitigating oxidative stress.

Research

Clinical Evidence

Low confidence
Effective range ≥1%
Optimal

N/A

Key findings

  1. 01 Antimicrobial effects against bacterial rhinosinusitis.
  2. 02 Claimed anti-wrinkle and elasticity benefits.

Transparency

Dusting Analysis

Not commonly dusted

No direct evidence suggests this ingredient is commonly 'dusted' at sub-efficacious concentrations. However, human clinical data for skin-specific efficacy of the isolated extract at typical cosmetic concentrations is insufficient, which could lead to overestimation of benefits based on general plant claims or preclinical/patent data.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Luffa Operculata Extract has not undergone review by the Cosmetic Ingredient Review (CIR) Expert Panel. It contains cucurbitacines and saponins, which are compounds associated with potential irritation and toxicity, particularly on mucous membranes. A 1% nasal solution was observed to cause an 'irritant effect on the respiratory tract,' and saponins are implicated in a 'caustic action over mucosas.' SkinSAFE indicates that products containing this extract are generally not categorized as 'Irritant Free,' suggesting a risk of skin irritation. The estimated oral toxic dose in humans is approximately 170 mg/kg, implying that roughly 1 gram of extract could be lethal for an average 70kg adult if ingested. It is also recommended 'not for fragrance use.'

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite possessing promising preclinical antimicrobial and antioxidant properties, Luffa Operculata Extract presents a high risk of irritation and lacks sufficient human clinical data for topical skin efficacy, rendering its use questionable in precision skincare.

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