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LIQUIDAMBAR ORIENTALIS BALSAM OIL.

Valuable CAS 94891-27-7 / PERFUMING

Liquidambar Orientalis Balsam Oil, derived from the sweetgum tree, is a multifaceted botanical extract known for its antioxidant, antimicrobial, and wound-healing properties. Precision studies indicate its ability to promote skin cell regeneration and protect against environmental stressors. However, its use requires careful formulation due to a potential for dermal sensitization.

Summary

Antioxidant Antimicrobial Wound Healing Skin Regenerative Perfuming

Science

Mechanism of Action

This balsam oil exerts its beneficial effects primarily through its rich phenolic content, which scavenges free radicals, thereby offering robust antioxidant protection. It demonstrates antimicrobial activity against both gram-positive (e.g., Staphylococcus aureus) and gram-negative bacteria (e.g., Escherichia coli). Furthermore, in vitro research suggests it stimulates keratinocyte proliferation and migration, critical processes for skin barrier repair and wound healing, potentially influencing collagen type-1 alpha-1 mRNA expression.

Research

Clinical Evidence

Medium confidence
Effective range 0.001 µg/mL–10 mg/mL%
Optimal

N/A

Key findings

  1. 01 In vitro studies at 0.001 µg/mL demonstrated a significant increase in HaCaT human keratinocyte cell proliferation and migration, indicating a contribution to wound healing. The ingredient was found non-toxic at concentrations up to 0.1 µg/mL.
  2. 02 In vitro testing revealed antimicrobial efficacy against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 10 mg/mL. Additionally, it exhibited considerable antioxidant activity across multiple assays (CUPRAC, FRAP, DPPH, ABTS+).
  3. 03 General in vitro experiments confirmed high antibacterial and antioxidant activities. Furthermore, it offered antioxidative and protective effects in rat livers.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.0000001% (0.001 µg/mL)%
Red flag below
0.6%

Efficacy for cellular proliferation and migration has been observed at extremely low concentrations (0.001 µg/mL), well below the maximum recommended safe concentration of 0.6%. This indicates that effective concentrations are achievable without exceeding safety limits, making 'dusting' (using ineffective amounts) unlikely when formulated appropriately within established guidelines.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Conflicts

  • Crude gums of Liquidambar orientalis are not recommended; only refined extracts or distillates (resinoids, absolutes, and oils) should be used in cosmetic applications.
  • Requires appropriate dilution with a suitable carrier oil for safe external application, particularly in massage or direct skin contact products.
  • Individuals with sensitivity to Balsam of Peru may experience cross-sensitization due to shared allergenic components.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.6%
Sensitization risk High

The Scientific Committee on Consumer Safety (SCCS) of the EU Commission has deemed Liquidambar Orientalis Balsam Oil safe for cosmetic use, provided specific restrictions are observed. Only extracts or distillates (resinoids, absolutes, oils) are permissible, not crude gums. The final concentration in consumer products must not exceed 0.6%, adhering to IFRA standards to mitigate dermal sensitization potential. Due to known potential for high irritancy and cross-sensitization, patch testing is advisable.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Liquidambar Orientalis Balsam Oil offers valuable antioxidant, antimicrobial, and regenerative benefits for skin health, but its high sensitization potential necessitates careful formulation and adherence to a maximum concentration of 0.6%.

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