Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

LIPASE.

Valuable CAS 9001-62-1 / SKIN CONDITIONING

Lipase is an enzymatic ingredient that targets the breakdown of skin lipids and triglycerides. It offers deep cleansing by emulsifying excess sebum and oils on the skin's surface, promoting skin renewal and refining texture without causing dryness or irritation.

Summary

Skin conditioning Hydrolyzes triglycerides Deep cleansing Gentle exfoliation

Science

Mechanism of Action

As an enzyme, Lipase specifically catalyzes the hydrolysis of fats, triglycerides, and oils. When applied to the skin, it acts on superficial lipids to effectively deep cleanse pores, reduce the likelihood of acne breakouts, and aid in the removal of dead skin cells. This action supports improved skin texture and maintains the skin's natural moisture balance.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Entrapment within polymeric nanofibrous matrices significantly enhanced specific enzyme activity, demonstrating potential for effective delivery of active substances, including lipases, to the human epidermis for targeted topical treatments.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding dusting practices for Lipase in skincare formulations is available.

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7.5
0 7 14

Stability

Lipase activity and product stability are highly dependent on precise pH control, ideally within a range of pH 5.5 to 7.5. While some microbial lipases show broader stability (e.g., pH 5-9 with optimal activity around pH 8-8.5), general reaction temperatures should remain mild, typically between 25 °C and 40 °C. It functions optimally at the oil-water interface.

Conflicts

  • Ingredients causing significant pH shifts outside the optimal range (5.5-7.5) can decrease enzyme effectiveness and stability.
  • Strong acids or alkalis will denature the enzyme, rendering it inactive.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Lipase enzyme preparations are classified as Generally Recognized As Safe (GRAS) by the FDA for food applications. For topical skincare, it is considered a gentle and skin-friendly ingredient, suitable even for sensitive skin, known for thorough cleansing without inducing irritation or dryness.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Lipase is a valuable enzymatic ingredient for gentle yet effective deep cleansing and skin renewal, suitable for all skin types due to its low irritancy and comedogenicity.

Related

Similar Ingredients

Finding similar ingredients…

References

Sources