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Moumoujus

LEVISTOLIDE A.

Insufficient Data CAS 88182-33-6 / SKIN CONDITIONING, SKIN PROTECTING

Levistolide A is a compound that has demonstrated diverse biological activities in preclinical studies. Notably, it exhibits in vitro inhibition of histamine release from mast cells, suggesting a potential role in mitigating inflammatory and allergic responses relevant to skin health. Further comprehensive research is required to ascertain its specific efficacy and safety for human dermal applications.

Summary

Anti-inflammatory Soothing

Science

Mechanism of Action

Levistolide A's primary mechanism of action relevant to skin involves its capacity to inhibit histamine release from HMC-1 human mast cell leukemia cells at a concentration of 10 µM. By modulating histamine, a key mediator in inflammatory and allergic reactions, Levistolide A may contribute to reducing skin redness and irritation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies at 10 µM demonstrated Levistolide A effectively inhibits histamine release induced by TPA and A23187 from HMC-1 human mast cell leukemia cells, indicating potential anti-inflammatory or anti-allergic effects.

Transparency

Dusting Analysis

Not commonly dusted

No data available regarding 'dusting' properties or common dusting practices for Levistolide A within cosmetic formulation contexts.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Levistolide A exhibits high solubility in various organic solvents including DMSO, Chloroform, and Ethanol. It shows limited solubility in aqueous buffers, with a reported solubility of 0.3 mg/ml in DMF:PBS (pH 7.2). It can be formulated in a carrier blend of 10% DMSO and 90% Corn Oil, indicating suitability for oil-based or emulsified systems.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Levistolide A has not undergone a formal safety assessment by the Cosmetic Ingredient Review (CIR). While a chemical supplier's product description includes a warning stating 'This product is not for human or veterinary use,' this typically pertains to its designation as a research reagent and does not constitute a comprehensive cosmetic safety evaluation. Without dedicated dermal safety data, its potential for sensitization or irritation in human skincare applications remains unknown.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite intriguing in vitro findings regarding anti-inflammatory potential, the absence of human-specific skincare efficacy data and a formal safety assessment renders Levistolide A currently unsuitable for precision skincare formulation.

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