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Moumoujus

LEVISTICUM OFFICINALE ROOT EXTRACT.

Avoid CAS 84837-06-9 / FRAGRANCE, PERFUMING, SKIN CONDITIONING

Derived from the lovage plant, Levisticum Officinale Root Extract is primarily recognized for its aromatic profile in cosmetic formulations. While it contains compounds with theoretical antioxidant and anti-inflammatory properties, its notable potential for skin sensitization and irritation makes it a concerning ingredient for precision skincare applications.

Summary

Antioxidant Anti-inflammatory Antiseptic Moisturizing Skin conditioning Fragrance

Science

Mechanism of Action

This extract is rich in phenolic compounds, including flavonoids (e.g., quercetin, rutin) and phenolic acids (e.g., chlorogenic, ferulic), which are potent antioxidants. Its anti-inflammatory effects are attributed to the inhibition of pro-inflammatory enzymes like COX-2 and LOX, alongside modulation of TNF-α and interleukins. The extract also possesses antiseptic properties, can condition the skin, and may offer moisturizing benefits by creating a protective barrier. However, the presence of volatile fragrant compounds, specifically phthalides and hydroxycinnamates, introduces a significant risk of skin sensitization.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The available clinical data pertains exclusively to in vitro cellular studies, not in vivo topical efficacy for specific skin benefits. Consequently, there is no established effective topical dose for Levisticum officinale root extract for human skin. Therefore, the concept of 'dusting' (using an active ingredient below its effective concentration for skin benefits) is not applicable, as its primary identified role in cosmetics often revolves around fragrance, which typically utilizes very low concentrations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This extract exhibits a shelf life of 6 months or longer when stored correctly in cool, dry, tightly sealed containers, protected from heat and light.

Conflicts

  • The volatile fragrant compounds within the extract are known to sensitize the skin, making it unsuitable for formulations targeting sensitive skin.
  • Lovage root oil CO2 extract has been classified as an irritant (R 36/38), indicating potential irritation to both skin and eyes, which suggests caution for the root extract as well.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

Levisticum Officinale Root Extract has not undergone specific review by the Cosmetic Ingredient Review (CIR) Expert Panel. The European Medicines Agency (EMA) advises against oral use of lovage root in individuals under 18, during pregnancy, or lactation due to insufficient safety data. This suggests a cautious approach for topical application as well. Although previously listed by FDA for food use as a natural flavoring, its FEMA GRAS™ status is no longer current. The confirmed presence of skin sensitizers and irritants presents a significant safety concern for topical cosmetic use.

Your Skin

Skin Compatibility

No Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the significant risk of skin sensitization and high irritancy, coupled with a lack of substantiated topical skin efficacy in human studies, Levisticum Officinale Root Extract is not recommended for inclusion in precision skincare formulations.

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