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Moumoujus

LEUKOCYTE EXTRACT.

Insufficient Data CAS 225234-41-3 / SKIN CONDITIONING

Leukocyte Extract is an active ingredient primarily recognized for its skin conditioning properties. When formulated, it demonstrates a notable capacity to enhance skin lightening and whitening effects, particularly in synergistic combinations with other brightening agents, while also contributing to slower repigmentation.

Summary

Skin conditioning Skin lightening Skin brightening

Science

Mechanism of Action

Operating primarily as a skin conditioning agent, Leukocyte Extract is understood to enhance the efficacy of skin lightening and whitening treatments. Its observed ability to sustain depigmentation and slow repigmentation suggests a potential influence on melanin synthesis or distribution pathways, though precise molecular mechanisms require further investigation.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–20%
Optimal

Studies indicate optimal efficacy within a concentration range of 0.5% to 20.0% by weight, particularly when synergistically combined with secondary lightening agents. Formulations operating within a pH of 3.0 to 7.0, with a preference for 4.0 to 6.5, demonstrated maximal benefits.

Key findings

  1. 01 US Patent 7,226,583 B2, demonstrating enhanced lightening, whitening, and slower repigmentation when combined with secondary agents.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

Efficacy is optimized within a pH range of 3.0 to 7.0, with a preferred window of 4.0 to 6.5. This water-soluble extract can be incorporated into diverse cosmetic forms, including liquids, lotions, creams, gels, serums, and pastes.

Synergies

  • Secondary lightening and/or whitening agents, for enhanced depigmentation and sustained results.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not conducted a safety assessment for Leukocyte Extract. As with many cosmetic ingredients, specific safety data regarding irritation, sensitization, or a maximum safe concentration is not readily available from regulatory bodies like the CIR or SCCS. The FDA primarily regulates cosmetic products post-market, placing the onus of safety substantiation on the manufacturer.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While demonstrating promising efficacy in skin lightening when paired with synergistic agents, a comprehensive safety profile and broader independent clinical data are currently limited, necessitating further research for widespread formulation.

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