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Moumoujus

LEUCOSIDEA SERICEA LEAF EXTRACT.

Valuable / ANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Leucosidea Sericea Leaf Extract is a botanical active revered for its multifaceted benefits, primarily its robust antimicrobial and anti-inflammatory properties. Rich in phytochemicals, it targets concerns such as acne, inflammation, and oxidative stress, making it suitable for oily, sensitive, and normal skin types.

Summary

Antimicrobial Anti-acne Anti-inflammatory Antioxidant

Science

Mechanism of Action

This botanical extract leverages its rich profile of phytochemicals, including phenolics, phloroglucinols, triterpenoids, alkaloids, and saponins. Its antimicrobial action encompasses broad-spectrum antibacterial activity against common skin bacteria like Propionibacterium acnes, Bacillus subtilis, and Staphylococcus aureus, potentially by inducing efflux of intracellular bacterial content. Anti-inflammatory effects stem from the inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, suppression of inflammatory cytokines such as interleukin 8 (IL-8) and tumor necrosis factor-alpha (TNF-α), and reduction of endothelial leukocyte adhesion molecule (ELAM). Furthermore, the extract delivers antioxidant protection through significant radical scavenging capabilities.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrates broad-spectrum antibacterial activity, inhibiting Bacillus subtilis and Staphylococcus aureus at a concentration of 0.025 mg/ml.
  2. 02 Exhibits potent activity against Propionibacterium acnes, with an ethanol leaf extract showing a minimum inhibitory concentration (MIC) of 15.7 µg/mL, and the isolated compound alpha kosin achieving an MIC of 1.9 µg/mL.
  3. 03 Provides significant anti-inflammatory benefits by inhibiting COX-1 with an IC50 as low as 0.06 µg/ml and COX-2 with an IC50 of 12.66 µg/ml (using a Petroleum Ether extract).
  4. 04 Further anti-inflammatory action is observed through the suppression of interleukin 8 (IL-8) and tumour necrosis factor (TNF-α) by ethanol extracts at concentrations between 6.2 and 25.0 µg/mL in human cell co-cultures.
  5. 05 Delivers antioxidant protection, with a methanol leaf extract showing up to 82.00% radical scavenging activity at 3000 µg/ml, and a specific compound (3,5,7,3´,4´-pentahydroxyflavone) demonstrating an EC50 of 14 µg/mL in DPPH assays.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not assessed Leucosidea Sericea Leaf Extract for safety. Preliminary in vitro tests indicate moderate cytotoxic effects on certain cell lines. While extracts were not mutagenic in the Ames test, methanolic leaf extracts, at concentrations up to 0.4 mg/ml, did not exhibit cytotoxicity or genotoxicity to Allium cepa root tip cells. However, when mixed with a known mutagen (Ethyl methanesulfonate, EMS) at 0.2 or 0.4 mg/ml, the combination demonstrated genotoxicity, with the 0.4 mg/ml mixture showing significantly greater genotoxic effects than EMS alone. Further safety assessment, particularly in vivo, is recommended.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Leucosidea Sericea Leaf Extract is a valuable botanical with demonstrated antimicrobial, anti-inflammatory, and antioxidant properties, making it promising for targeted skin concerns, though further in vivo human safety and efficacy studies are needed.

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