Science
Mechanism of Action
This extract primarily inhibits melanin biosynthesis by targeting tyrosinase, a key enzyme in melanin production. Its isolated compound, dalbergioidin, acts as a noncompetitive inhibitor of tyrosinase. Additionally, lipophilic flavonoids sourced from the roots of Lespedeza cyrtobotrya have demonstrated the ability to suppress melanin synthesis in normal human epidermal melanocytes.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Dalbergioidin, a constituent isolated from Lespedeza cyrtobotrya, exhibited significant tyrosinase inhibitory activity with an IC50 of 20 mM.
- 02 Dalbergioidin reduced melanin content by over 50% in immortalized mouse melan-a cells at a concentration of 27 mM.
- 03 Lipophilic flavonoids extracted from the roots effectively inhibited melanin synthesis in normal human epidermal melanocytes.
- 04 A methanol extract of Lespedeza cyrtobotrya demonstrated inhibitory activity against mushroom tyrosinase.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments by major regulatory bodies such as CIR, SCCS, or FDA were found for Lespedeza Cyrtobotrya Extract in the available data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable botanical ingredient with robust in vitro evidence for tyrosinase inhibition and melanin reduction, positioning it as a promising candidate for hyperpigmentation solutions, pending further comprehensive safety and in vivo efficacy data on the full extract.
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References
Sources