Science
Mechanism of Action
This extract promotes skin rejuvenation by significantly increasing the synthesis of extracellular matrix (ECM) components and critical cell surface receptors, such as integrins, within normal human epidermal keratinocytes. These actions are fundamental for maintaining cellular architecture, promoting mobility, and regulating the cell cycle, thereby enhancing the skin's overall strength and function. Enriched with macaene, macamides, and vitamins C, D, and E, it further supports collagen synthesis, provides antioxidant defense against free radicals, and demonstrates potential anti-melanogenic, anti-inflammatory, and anti-wrinkle benefits.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 An in vitro study on normal human epidermal keratinocytes (NHEK) demonstrated a significant increase in the synthesis of extracellular matrix (ECM) components and cell surface receptors, which are crucial for mediating intracellular signals.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Antioxidant activity of maca extract in a beverage was observed to decrease after four weeks when stored at 4°C and 37°C. While heat treatment for 10 minutes did not significantly alter color, polyphenols, or antioxidant activities in a beverage, nitrite scavenging abilities, indicative of antioxidant capacity, were pH-dependent. This activity diminished as pH increased, disappearing by pH 6.0, with maximum effect observed at pH 1.2.
Safety
Safety Profile
The Food and Agriculture Organization (FAO) recognized Maca as a safe edible food in 1992. The United States Pharmacopeia (USP-NF) initiated an evaluation for dietary ingredients derived from maca in 2009. General chemical safety assessments indicated 'None found' for GHS classification and hazard statements, with oral, dermal, and inhalation toxicity noted as 'Not determined' in a broad context.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable botanical extract with promising in vitro data demonstrating enhanced ECM and cell receptor synthesis, suggesting significant potential for skin strengthening and anti-aging benefits, though further human clinical trials for topical application are recommended.
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References
Sources