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Moumoujus

LEDEBOURIELLA DIVARICATA ROOT EXTRACT.

Valuable / SKIN CONDITIONING

Ledebouriella Divaricata Root Extract, also known as Fang Feng, is a botanical powerhouse recognized for its multi-faceted benefits in skincare. It offers significant anti-inflammatory and antioxidant capabilities, alongside notable skin conditioning and antimicrobial properties. This ingredient works to soothe skin, protect against environmental stressors, and support overall skin health.

Summary

Anti-inflammatory Antioxidant Skin conditioning Antimicrobial

Science

Mechanism of Action

This root extract exerts its anti-inflammatory effects primarily by significantly reducing nitric oxide (NO) production and inhibiting the expression of iNOS (inducible nitric oxide synthase) mRNA in activated cells. Beyond inflammation modulation, it provides antioxidant protection, and acts as a skin conditioning agent by promoting a healthy skin barrier. Traditionally employed for its ability to alleviate discomfort and address various skin disorders like eczema and dermatitis, it also possesses antimicrobial properties to help inhibit the growth of microorganisms.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.05%
Optimal

0.05%

Key findings

  1. 01 Dose-dependently and significantly reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 cells, demonstrating potent anti-inflammatory effects. The 0.05% concentration specifically led to a significant reduction in iNOS mRNA expression.

Transparency

Dusting Analysis

Not commonly dusted

No data available in research to suggest this ingredient is commonly dusted or used at ineffective percentages in the industry.

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 11.5
0 7 14

Stability

A 1% (w/v) formulation in Milli Q water demonstrated excellent stability across a broad pH range of 2 to 11.5, with a measured pH of 4.67. Its versatility allows for preparation as an alcohol-free glycerite or an alcohol-based tincture.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The ingredient is listed in the FDA Global Substance Registration System (UNII: 8H84LFK2QD). EWG's Skin Deep® database indicates a low concern for 'Allergies & Immunotoxicity'. A 1% (w/v) transdermal application on New Zealand white rabbits was found to be non-irritating, supporting its mild profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Ledebouriella Divaricata Root Extract is a valuable botanical ingredient, offering confirmed anti-inflammatory, antioxidant, and skin conditioning benefits with a broad pH stability and low irritancy profile for diverse skin types.

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