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Moumoujus

LAWSONIA INERMIS CALLUS CULTURE EXTRACT.

Avoid / ANTIOXIDANT

This extract, derived from the callus cultures of Lawsonia Inermis (Henna), contains a rich array of phytochemicals including flavonoids, polyphenols, and lawsone. These compounds are associated with antioxidant, anti-inflammatory, and antimicrobial properties.

Summary

Antimicrobial Antioxidant Anti-inflammatory Hair Dyeing Hair Conditioning Skin Conditioning

Science

Mechanism of Action

The extract's biological activity is attributed to its diverse phytochemical composition, particularly flavonoids, polyphenols, and lawsone. These constituents exert antioxidant effects by neutralizing free radicals, and contribute to observed anti-inflammatory and antimicrobial actions. Lawsone specifically interacts with keratin, a protein in skin and hair, which is the basis for its dyeing capabilities.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted

While the parent plant Lawsonia Inermis is recognized for its beneficial compounds, specific clinical studies demonstrating effective concentrations for this callus culture extract on skin are currently unavailable. Its inclusion in formulations may sometimes leverage the general properties of the plant rather than extract-specific efficacy data.

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 9
0 7 14

Stability

Optimal activity appears to be maintained within a pH range of 7.0 to 9.0, with diminished efficacy observed at lower pH values, such as 4.0.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Scientific Committee on Consumer Safety (SCCS) has expressed significant concerns regarding lawsone, a prominent component of Lawsonia Inermis and likely present in this extract, citing its 'genotoxicity/mutagenicity potential in vitro and in vivo' and concluding that 'no safe threshold for Lawsone can be established.' Although a human repeat insult patch test (HRIPT) with 10% Lawsonia inermis extract in petrolatum indicated low skin sensitization risk, and an Australian assessment found low acute toxicity at low concentrations, the SCCS's genotoxicity finding for lawsone is a critical safety consideration.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite potential antioxidant and antimicrobial properties, the significant genotoxicity/mutagenicity concerns regarding its constituent lawsone, for which no safe threshold has been established by the SCCS, render this ingredient unsuitable for precision skincare formulations.

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