Science
Mechanism of Action
Laudanosine's known pharmacological mechanisms involve interactions with neurological receptors, including competing with acetylcholine and blocking ionic pores. However, no specific mechanism of action or cosmetic benefit on skin has been identified or studied.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
There is no evidence or common use of Laudanosine as an active ingredient in skincare formulations, therefore dusting is not applicable in this context.
The Formula
Formulation
Stability
Laudanosine is produced via the spontaneous degradation of atracurium at physiological pH and temperature. It demonstrates solubility in water (approximately 74.73 mg/L at 25 °C) and is also soluble in various organic solvents, including DMSO (100 mg/mL), ethanol, and methanol. Optimal pH for its stability within skincare formulations has not been specified.
Safety
Safety Profile
Laudanosine is associated with significant systemic toxicity, including the potential to induce excitement and seizure activity, and impact cardiovascular function (hypotension, bradycardia) at sufficient concentrations. It is also known to cross the blood-brain barrier and can decrease the seizure threshold. No dedicated safety assessments by regulatory bodies (CIR, SCCS, FDA) for its use as a topical skincare ingredient have been conducted, and its elimination can be prolonged in cases of hepatic or renal failure.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its documented systemic toxicity, ability to cross the blood-brain barrier, and the complete lack of any evidence for topical skin benefits or specific safety assessments for cosmetic use, Laudanosine is strongly advised against inclusion in skincare formulations.
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References
Sources