Science
Mechanism of Action
This extract functions as an antioxidant by inhibiting oxygen-promoted reactions, thereby preventing cellular and ingredient oxidation and deterioration. It actively offers skin protection against various external influences. Extracts from Larix decidua, particularly its bark, are rich in procyanidins (PACs) and other polyphenols. These compounds have been shown to exert antimicrobial effects by inhibiting microbial enzymes, disrupting cell membranes, and interfering with microbial metabolism. Furthermore, studies indicate anti-inflammatory effects and wound healing properties, alongside inhibitory activity against collagenase, elastase, and tyrosinase, which may collectively contribute to anti-aging and skin brightening benefits.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 While direct clinical efficacy data specifically for LARIX DECIDUA LEAF CELL EXTRACT is still emerging, studies on other Larix decidua forms highlight its potential. Larch bark extracts (60-300 μg/ml) have demonstrated significant inhibition of skin enzymes, including over 80% elastase inhibition at 300 μg/ml, greater than 90% collagenase inhibition at 150 μg/ml, and approximately 50% tyrosinase inhibition at 300 μg/ml. Separately, Larch Bark Extract (2-200 μg/mL) showed antimicrobial activity against respiratory-tract pathogens, with inhibition ranging from 10% to 42% depending on the strain and concentration (e.g., 42% inhibition for P. aeruginosa at 200 µg/mL). Larix decidua resin has also exhibited potential for topical wound healing in animal models.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Larix decidua resin and its extracts are generally regarded as safe and well-tolerated. Animal studies involving oral intake showed no harm, and topical applications are anticipated to be safe. In vitro cytotoxicity tests indicated that Larch Bark Extract (LBE) at concentrations up to 2000 µg/mL did not reduce the viability of human alveolar basal epithelial cells. An acute oral toxicity study in rats reported an LD50 exceeding 5000 mg/kg body weight, with no signs of toxicity or mortality observed. While mild, transient contact dermatitis has been noted with certain plant extracts, it typically resolves upon discontinuation. The CIR has not yet reviewed this specific ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Larix Decidua Leaf Cell Extract is a valuable ingredient primarily for its direct antioxidant and skin-protecting capabilities, with strong evidence from other Larix decidua extracts suggesting broader anti-aging, brightening, and anti-inflammatory benefits.
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