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LACTOSE.

Valuable CAS 63-42-3 / HUMECTANT, SKIN CONDITIONING

Lactose is a disaccharide that functions as a multi-faceted skin conditioner. It enhances skin hydration as a humectant and fosters a balanced microbiome through its prebiotic properties, leading to improved skin texture and strengthened barrier function.

Humectant Skin conditioning Prebiotic Exfoliant (mild) Stabilizer

Science

Lactose acts as a humectant, drawing and retaining moisture from the surrounding air to boost skin hydration, contributing to a softer, more supple feel and fortifying the skin's natural barrier. It also serves as a skin-conditioning agent, refining skin texture and minimizing flakiness. Furthermore, lactose exhibits prebiotic properties, providing a nutrient source for beneficial skin bacteria like Lactobacillus and Bifidobacteria, thereby promoting a balanced skin microbiome which can help reduce inflammation and control acne. When metabolized by Lactobacillus, lactose produces Lactic acid, a natural moisturizing factor (NMF) and a mild alpha-hydroxy acid (AHA) that aids in gentle exfoliation and cell renewal. It can also enhance the action of other active ingredients and act as a stabilizer in cosmetic formulations.


Research

Medium confidence
Effective range N/A
Optimal

2.48%

Key findings

  1. 01 A face and neck formulation containing 2.48% lactose demonstrated no irritation or hypersensitivity in a 4-week ophthalmological safety-in-use evaluation.
  2. 02 Topical application of a cream combining retinol, lactose, and glycolic acid significantly improved the appearance of photodamaged skin over a 12-week period.

Transparency

Not commonly dusted

Lactose is freely but slowly soluble in water; its low solubility can lead to crystallization in supersaturated solutions, potentially resulting in a gritty texture. Additionally, lactose powders may undergo plasticization, becoming sticky and prone to caking when exposed to humidity or high temperatures. These are formulation challenges, not an indication of being commonly dusted for marketing purposes.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Lactose dissolves slowly in water, and its tendency to crystallize in supersaturated solutions can result in a gritty product texture. Lactose powders are susceptible to plasticization, becoming sticky and caking when exposed to high humidity or temperatures. While a specific optimal pH for lactose stability is not detailed, skincare products typically aim for a pH between 4.5 and 5.5 to support overall stability and skin barrier function.

Synergies

  • Enhances the action of other active ingredients, as observed when combined with retinol and glycolic acid.
  • Produces Lactic acid through bacterial metabolism, complementing other exfoliating and hydrating actives.

Safety

CIR Status
Safe as used
Max tested
2.48%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that lactose is safe for use in cosmetics. A 4-week ophthalmological safety evaluation confirmed that a 2.48% lactose formulation did not induce irritation or hypersensitivity. However, individuals with diagnosed lactose intolerance or milk allergies should proceed with caution due to the potential for adverse reactions, although digestive issues are rare with topical application.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Lactose is a valuable ingredient for its hydrating, skin-conditioning, and microbiome-balancing properties, offering broad skin compatibility and a low risk of irritation at concentrations up to 2.48%.


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