Science
Mechanism of Action
The ingredient exerts its beneficial effects through multifaceted mechanisms. It actively modulates the skin's microbiome by fostering the growth of beneficial bacteria while deterring pathogenic strains, thereby achieving ecological balance. By upregulating tight junction proteins, it reinforces the skin barrier, leading to a measurable reduction in transepidermal water loss (TEWL) and enhanced skin hydration. Its potent anti-inflammatory properties soothe irritation, making it advantageous for conditions like acne and rosacea, and accelerating recovery from environmental stressors such as UV exposure. Furthermore, it supports natural DNA repair, boosts keratinocyte proliferation and migration for accelerated cellular renewal, and may offer mild enzymatic exfoliation. Specific components derived from Lactobacillus can also inhibit melanin synthesis, contributing to a reduction in hyperpigmentation.
Research
Clinical Evidence
Medium confidence5%
Key findings
- 01 A 5% concentration of Lactobacillus Ferment Lysate Filtrate demonstrated a 47% reduction in skin redness in an in-vivo study involving 5 subjects.
- 02 In a Human Repeat Insult Patch Test (HRIPT) with 50 subjects, a product containing 5% Lactobacillus Ferment Lysate Filtrate was confirmed to be non-irritating and non-sensitizing.
- 03 A lotion containing a blend of fermented lysates, including Lactobacillus strains, significantly decreased transepidermal water loss (TEWL) and redness, and increased skin moisturization after 30 days of use.
- 04 Postbiotic creams formulated with Lactobacillus ferment lysate improved the SCORAD index in pediatric patients with Atopic Dermatitis over two months, exhibiting a lower recurrence rate after four months compared to placebo.
Transparency
Dusting Analysis
The ingredient's efficacy is substantiated by clinical studies demonstrating tangible benefits at specified concentrations, indicating it is not typically 'dusted' for marketing claims.
The Formula
Formulation
Stability
The lysate complex maintains chemical stability at standard ambient conditions (room temperature) for approximately one year and is readily incorporated into both aqueous systems and emulsions. Optimal stability has been observed around pH 6.00 ± 0.02. To preserve its integrity, exposure to freezing temperatures and strong oxidizing agents should be avoided.
Conflicts
- Extremes of temperature (do not freeze)
- Strong oxidizers
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Lactobacillus Ferment, its lysate, and lysate filtrates are safe for cosmetic use under current practices. Related Leuconostoc ferments have also been found to be non-sensitizing. Polysorbate 80, used in the fermentation process, is categorized as low-risk, generally non-irritating, and non-comedogenic. While overall safety risk is low, patch testing is advisable for individuals with highly sensitive skin. No genotoxicity was observed in Ames assays, and phototoxicity assays indicated no phototoxicity at lower concentrations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This advanced postbiotic ingredient offers multifaceted benefits, demonstrably enhancing skin barrier function, reducing redness, and supporting a healthy microbiome across all skin types.
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References
Sources