Science
Mechanism of Action
This multi-component ingredient exerts its effects through several pathways. The Lactobacillus ferment components act as DNA repair enzymes, enhance oxygen uptake, stimulate collagen production, and boost ATP synthesis at a cellular level (in-vitro), while also protecting against environmental stressors. It possesses antimicrobial and anti-inflammatory properties, potentially balancing skin microflora to mitigate acne and rosacea, and has been observed to reduce acne lesion size and redness more rapidly than salicylic acid. Leuconostoc ferment filtrate offers anti-seborrheic and antimicrobial benefits. Fermented broccoli extracts significantly increase antioxidant activity and provide anti-inflammatory effects. Additionally, broccoli extract components, such as NMN, contribute to enhanced skin hydration by promoting hyaluronic acid and extracellular matrix components, thereby improving barrier integrity by reducing oxidative stress and inhibiting inflammatory cascades. Collectively, these probiotic constituents intensively moisturize, reduce transepidermal water loss, energize skin bacteria, and contribute to overall skin repair and elasticity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Lactobacillus Ferment Lysate Filtrate demonstrated a 47% reduction in facial redness in an in-vivo study involving 5 participants.
- 02 Lactobacillus ferment exhibited effective anti-acne properties.
- 03 Lactobacillus ferment significantly reduced skin sensitivity.
- 04 Fermented broccoli extracts increased antioxidant activity, inhibited proliferation of specific cell lines (HT29 and HT116), and showed anti-inflammatory effects.
Transparency
Dusting Analysis
Information regarding 'dusting' for this specific ingredient is not available in the provided research data.
The Formula
Formulation
Stability
The Leuconostoc ferment extract component is active across a broad pH range (3.0-8.0), with its own pH naturally falling between 4.0-6.6. It maintains stability at temperatures up to 60°C (140°F). For optimal integration, it is recommended to incorporate this ingredient during the cooling phase of formulation, ensuring temperatures remain below 60°C (140°F).
Conflicts
- highly anionic ingredients
- thickeners (e.g., xanthan gum)
Safety
Safety Profile
The CIR Expert Panel has confirmed that Lactobacillus Ferment, its filtrates, and lysates are safe for cosmetic application, showing no genotoxicity in Ames assays and being non-irritating at 100% concentration in EpiOcular assays. Leuconostoc Ferment Extract is also categorized as non-toxic, non-irritating, and non-sensitizing. It's important to note that postbiotics derived from Lactobacillus bacteria, particularly those acting as tyrosinase-inhibitors, could potentially lead to skin depigmentation, which is considered a drug effect. Formulators must ensure the ingredient's use does not induce this specific outcome.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ferment filtrate is a valuable multifunctional ingredient, offering comprehensive benefits for skin health including barrier support, redness reduction, and antioxidant protection, with a favorable safety profile.
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References
Sources