Science
Mechanism of Action
The Angelica Keiskei component provides robust antioxidant and anti-inflammatory protection, shielding the skin from oxidative stress and environmental damage. This contributes to the reduction of fine lines, alleviation of irritation, and support for skin hydration, mediated by bioactive substances like flavonoids. It also exhibits potential to inhibit melanin production, acting both as an antioxidant and by inhibiting α-MSH. Concurrently, the Lactobacillus ferment filtrate component, as a fermentation-derived active, delivers a rich array of postbiotics including metabolites, peptides, enzymes, and vitamins. These compounds work to strengthen the skin's intrinsic barrier function, improve hydration levels, and foster a balanced skin microbiome. Additionally, it displays anti-microbial and further anti-inflammatory effects, and can stimulate the production of beta-defensins in skin cells.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A 1% concentration of Lactobacillus ferment demonstrated efficacy in reducing skin sensitivity.
- 02 Lactobacillus ferment at 5% was effective in anti-acne applications, reducing both the size and redness of acne lesions.
- 03 In a confined in-vivo study involving 5 participants, a 5% Lactobacillus Ferment Lysate Filtrate showed a 47% reduction in skin redness.
- 04 An 8% Ashitaba (Angelica keiskei) leaves extract cream inhibited the increase of melanin amount in UVB-exposed guinea pig skin, proving as effective as a 4% hydroquinone cream.
Transparency
Dusting Analysis
No specific data regarding dusting practices or thresholds for this precise combined ingredient were identified in the available research.
The Formula
Formulation
Stability
Ferment filtrates typically exhibit broad pH tolerance, offering significant flexibility in water-based formulations. While related forms like lysates may show optimal performance around pH 5-6, filtrates are generally stable across a wider pH spectrum.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that general Lactobacillus ferment ingredients, including filtrates, are safe for use in cosmetics at current concentrations and practices. The highest reported maximum concentration of use for Lactobacillus Ferment is up to 5.6% in face and neck products. No genotoxicity was observed in Ames assays for Lactobacillus Ferment or related forms. This assessment is specific to the Lactobacillus ferment component and not explicitly for the combined LACTOBACILLUS/ANGELICA KEISKEI LEAF/STEM EXTRACT FERMENT FILTRATE.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-functional ferment filtrate offers significant potential for enhancing skin resilience, reducing inflammation and redness, and promoting a more even, hydrated complexion, positioning it as a valuable asset in precision skincare formulations.
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References
Sources