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Moumoujus

LACTATE DEHYDROGENASE.

Insufficient Data CAS 9001-60-9 / SKIN CONDITIONING

Lactate Dehydrogenase (LDH) is an enzyme central to cellular energy metabolism, facilitating the conversion of pyruvate to L-lactate, particularly under anaerobic conditions. While essential for biological function, its current scientific application is predominantly as a diagnostic biomarker for detecting tissue damage and disease, not as an active cosmetic ingredient.

Summary

Science

Mechanism of Action

As an enzyme, Lactate Dehydrogenase (LDH) precisely catalyzes the reversible interconversion of pyruvate and L-lactate. This biochemical reaction is coupled with the critical interconversion of NAD+ and NADH cofactors, enabling cells to generate adenosine triphosphate (ATP) through anaerobic glycolysis when oxygen levels are low.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Lactate Dehydrogenase is not a commonly utilized ingredient in cosmetic formulations, as its primary role is in medical diagnostics and laboratory research. Consequently, it is not considered to be an ingredient subject to "dusting" or exaggerated claims within the skincare industry.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 7.3
0 7 14

Stability

LDH exhibits enhanced stability when stored at -20°C, particularly in the presence of cryoprotectants such as polyethylene glycol (PEG). Its enzymatic activity is optimal within a neutral to slightly alkaline pH range, specifically between 6.0 and 7.3, with examples citing pH 7.0 at 25°C. Weak interactions with nonionic surfactants like Tween 80 have been observed but are generally not potent enough to induce denaturation. Mercaptans can reverse the inhibitory effects of thiol-attacking reagents, and sodium sulfite offers additional protective benefits.

Synergies

  • Polyethylene glycol (PEG) for cryoprotection
  • Mercaptans for reversing thiol-attacking inhibition
  • Sodium sulfite for general enzyme protection

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Lactate Dehydrogenase is primarily recognized in medical diagnostics as a biomarker for tissue damage and disease, not as a cosmetic ingredient. A safety data sheet for LDH as a laboratory chemical indicates it does not meet GHS classification criteria and is not listed as an endocrine disruptor. However, comprehensive safety evaluations specific to cosmetic applications are currently unavailable.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

With no identified cosmetic benefits, clinical studies supporting topical efficacy, or dedicated safety reviews for skincare applications, there is insufficient data to recommend Lactate Dehydrogenase in cosmetic formulations.

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