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LACTAMIDE.

Questionable CAS 2043-43-8 / SKIN CONDITIONING

Lactamide is a monocarboxylic acid amide derived from lactic acid. While its direct mechanism for specific skincare benefits remains largely undefined, its close derivative, Lactamide MEA, is recognized for its conditioning and humectant properties.

Skin conditioning

Science

As a lactic acid derivative, Lactamide is formed by converting the carboxylic acid group of lactic acid into a carboxamide. The research does not extensively detail Lactamide's direct mechanism of action for specific skincare benefits like exfoliation or anti-aging. However, its widely used derivative, Lactamide MEA, functions as a skin conditioning agent and a humectant, suggesting a potential for similar moisture-retaining and skin-softening effects for Lactamide itself, though this is not explicitly confirmed for the parent compound.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Skincare formulations incorporating Lactamide require precise pH control, ideally within the range of 4.5-6.5, to ensure product stability and maintain compatibility with the skin's natural barrier, which has a pH of approximately 5.5. Lactamide compounds are also noted for their excellent solubilizing capabilities, allowing their use as effective solvents within formulations.

Conflicts

  • Incompatible substances
  • Sources of ignition

Safety

CIR Status
Safe with restrictions
Sensitization risk High

Lactamide itself is identified as an irritant, with GHS classifications indicating it 'Causes skin irritation' and 'Causes serious eye irritation'. For its derivative, Lactamide MEA, the Cosmetic Ingredient Review (CIR) determined it safe for cosmetic use under specific qualifications. Critically, it is deemed 'unsafe in products left on skin and not rinsed off' due to potential issues related to use, concentration, or manufacturing constraints. No specific SCCS opinion or FDA status for Lactamide itself was found.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Questionable

Due to its identified irritant nature and the limited direct data on its specific skincare benefits, Lactamide's inclusion in precision skincare formulations is questionable, necessitating careful consideration of its derivative's restrictions for leave-on products.


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