Science
Mechanism of Action
This extract combats oxidative stress by effectively scavenging free radicals, attributed to its rich content of phenolics, flavonoids, beta-carotene, and ascorbic acid. It mitigates inflammatory responses, particularly those induced by UVB radiation, by inhibiting key mediators such as TNF-alpha and COX-2. As an anti-photoaging agent, it actively restores collagen synthesis and downregulates the expression of matrix metalloproteinases (MMP-1 and MMP-9) that degrade collagen following UV exposure. Additionally, it may offer cytoprotective benefits via quercetin, potentially contribute to skin brightening by reducing tyrosinase activity, and exhibits antimicrobial properties through saponins and benzoquinone derivatives, promoting overall skin health and wound healing.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 At a concentration of 0.006%, the extract demonstrated 50% free radical scavenging activity (FSC50), a potency comparable to 156 µM ascorbic acid, indicating robust antioxidant capabilities against photoaging.
- 02 In human fibroblasts, a dose-dependent application effectively restored collagen synthesis, which was diminished by UVB exposure, back to normal levels. It concurrently downregulated the enhanced expression of MMP-1 and inhibited the production of inflammatory markers like TNF-alpha and COX-2 following UVB irradiation.
- 03 A 2.0% aqueous extract significantly accelerated wound contraction and promoted healing in a rat model of superficial partial thickness burn wounds, suggesting strong reparative potential.
Transparency
Dusting Analysis
No specific data regarding dusting or common under-dosing practices for Labisia Pumila Leaf/Root Extract was identified in the available research.
The Formula
Formulation
Stability
While a pH range of 6.0-6.8 was noted for hydrolyzed tissue analysis in one study, specific optimal pH ranges for the stability of Labisia Pumila Leaf/Root Extract within cosmetic formulations are not explicitly detailed in the provided research.
Safety
Safety Profile
The European Food Safety Authority (EFSA) has assessed an aqueous ethanolic extract of Labisia pumila as a 'novel food,' considering daily oral intake up to 5 mg/kg body weight (equivalent to 350 mg/day for adults, excluding pregnant/lactating women) to be safe. Animal studies indicate a very high LD50 (>5.0 g/kg) and established No-Adverse-Effect-Levels (NOAEL) at significant dosages (50 mg/kg sub-acute, 1000 mg/kg sub-chronic, 800 mg/kg reproductive toxicity). Randomized, placebo-controlled clinical trials have also reported safe oral consumption in postmenopausal women, with no acute toxicity documented in oral studies. However, specific topical safety assessments regarding maximum concentration or sensitization risk for cosmetic use are not extensively detailed.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Labisia Pumila Leaf/Root Extract is a valuable, multifaceted botanical asset, demonstrating robust antioxidant, anti-inflammatory, and collagen-protective actions, with promising data from in vitro and animal studies and a favorable safety profile from oral consumption. Further specific topical safety and efficacy data would elevate its profile.
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References
Sources