Science
Mechanism of Action
The extract's activity is primarily driven by its sesquiterpene lactones (STLs), which are responsible for triggering allergic dermatitis and inducing phototoxic responses when applied to the skin. Additionally, it contains pyrrolizidine alkaloids (PAs), which are highly hepatotoxic and cardiotoxic if ingested. No beneficial mechanisms of action on the skin have been established for this ingredient.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
This ingredient is not commonly found in cosmetic formulations due to its inherent toxicity. There is no evidence suggesting it is 'dusted' in products for perceived benefits, as its inclusion is strongly advised against.
The Formula
Formulation
Conflicts
- Jacobaea vulgaris extract contains pyrrolizidine alkaloids and sesquiterpene lactones, which are known to cause severe skin reactions like allergic dermatitis and phototoxicity. Its use in any cosmetic formulation is highly contraindicated.
Safety
Safety Profile
Jacobaea vulgaris is classified as a noxious weed due to its potent toxins. Topically, its sesquiterpene lactones frequently trigger allergic dermatitis and phototoxicity, with documented instances of acute blistering. Ingestion of its pyrrolizidine alkaloids poses significant hepatotoxic and cardiotoxic risks.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its documented toxicity, high risk of severe skin reactions, and complete absence of beneficial dermatological effects, Jacobaea vulgaris extract is an ingredient to be entirely avoided in skincare formulations.
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References
Sources