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ISOVALERIC ACID.

Avoid CAS 503-74-2 / PERFUMING

Isovaleric acid is a branched-chain short-chain fatty acid recognized for its distinctive strong odor, commonly associated with foot odor. While its esters are utilized in perfumery, the acid itself is corrosive to tissue and should not be used in skincare formulations.

fragrance

Science

This compound demonstrates no identified beneficial mechanism of action on the skin within a cosmetic application. Instead, it functions as a potent corrosive agent, leading to severe tissue damage and chemical burns upon direct contact.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Isovaleric acid is a stable compound with a pKa of 4.77 at 25°C. Its solutions are notably acidic, registering pH 3.92 at 1mM, pH 3.4 at 10mM, and pH 2.89 at 100mM concentrations.

Conflicts

  • oxidizing agents
  • bases
  • strong reducing agents
  • alkalis
  • chemicals readily decomposed by acids (e.g., cyanides, sulfides, carbonates)
  • metals (e.g., mild steel, galvanized steel, zinc)

Safety

CIR Status
Not reviewed
Sensitization risk High

Isovaleric acid is classified as corrosive to metals and biological tissue, capable of inducing severe skin burns and serious eye damage. It is harmful if ingested or inhaled. While the FDA lists it as 'Generally Recognized As Safe' (GRAS) for specific food flavoring uses (21 CFR 172.515), this designation does not extend to topical cosmetic applications. Direct contact with open cuts, abraded, or irritated skin must be strictly avoided.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

Due to its corrosive nature, severe irritancy potential, and lack of identified skin benefits, Isovaleric Acid is entirely unsuitable for use in cosmetic skincare formulations and should be actively avoided.


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