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ISOSTEARAMIDOPROPYL DIMETHYLAMINE.

Questionable CAS 67799-04-6 / ANTISTATIC

Isostearamidopropyl Dimethylamine is an amidoamine compound that functions as a cationic emulsifier, antistatic agent, lubricant, and conditioning ingredient. It is primarily utilized for its ability to stabilize oil-in-water emulsions, reduce static charge, and enhance skin and hair texture.

Summary

antistatic agent cationic emulsifier lubricant hair conditioner skin conditioner

Science

Mechanism of Action

As a cationic amidoamine, Isostearamidopropyl Dimethylamine primarily functions by stabilizing oil-in-water emulsions through its amphiphilic structure, interacting with both lipid and aqueous phases. Its positive charge confers antistatic properties, making it effective in hair care. Additionally, it provides lubricating and conditioning effects, imparting a smoother feel to skin and hair surfaces.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Requires meticulous formulation to ensure it is non-sensitizing. Stability is paramount as impurities, specifically 3,3-dimethylaminopropylamine (DMAPA), are known to increase dermal sensitization risk.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.04%
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Isostearamidopropyl Dimethylamine is safe for use in cosmetic products when formulated to be non-sensitizing. Specific maximum usage concentrations are 0.38% in rinse-off products and a more stringent 0.04% in leave-on products. This ingredient is identified as a potential dermal sensitizer, largely due to potential contamination by 3,3-dimethylaminopropylamine (DMAPA). Raw material classifications via ECHA GHS indicate it can cause skin irritation and serious eye damage. Some regulatory summaries, such as EWG's interpretation of CIR findings, advise against its use in products intended to be left on the skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While providing valuable conditioning and emulsifying properties, Isostearamidopropyl Dimethylamine's stringent concentration limits for leave-on products, potential for sensitization from impurities, and raw material irritancy classify it as questionable for precision skincare, particularly in leave-on applications.

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