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Moumoujus

ISOQUERCETIN.

Valuable CAS 482-35-9 / ANTIOXIDANT

Isoquercetin, a potent flavonoid and quercetin glycoside, offers multi-faceted benefits for skin. It functions as a powerful antioxidant and anti-inflammatory agent, actively working to mitigate skin irritation and protect against environmental stressors contributing to photoaging.

Summary

Antioxidant Anti-inflammatory Anti-photoaging Improves skin barrier function Improves skin elasticity Reduces skin roughness

Science

Mechanism of Action

This ingredient exerts its effects through several key pathways. As an antioxidant, it neutralizes free radicals, preventing cellular damage and ingredient degradation. Its significant anti-inflammatory action stems from its ability to reduce the overexpression of pro-inflammatory messengers, such as IL-6 and CXCL8, in activated keratinocytes, potentially by modulating ERK and p38 phosphorylation. Isoquercetin also helps prevent histamine release and has shown potential to reduce collagen degradation, thereby supporting skin structure.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Isoquercetin is supported by specific in vitro, in vivo, and clinical data demonstrating its anti-inflammatory and antioxidant properties, with observed effects at precise concentrations in vitro. This indicates it is an active ingredient rather than one commonly used at ineffective 'dusting' levels.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Isoquercetin generally exhibits enhanced water solubility compared to its aglycone, quercetin. While specific optimal pH ranges are not fully defined for isoquercetin, related research suggests stable emulsion systems can be maintained across a pH range of 3.0-9.0, with potentially improved stability around pH 3.0. To preserve its functionality, cold storage (e.g., 4 ± 2°C) is advisable, as significant degradation and loss of antioxidant activity have been observed at elevated temperatures (e.g., 30°C/70% RH after 6 months, or 40°C/70% RH after 2 months). Its relatively higher lipophilicity also contributes to better skin permeation compared to other glycosides like rutin.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Isoquercetin is recognized by the FDA (UNII 6HN2PC637T), but no specific 'safe as used' or 'restricted' cosmetic status has been issued by the CIR or SCCS. In vitro studies indicate no cytotoxic effects at concentrations up to 100 μM.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Isoquercetin is a valuable antioxidant and anti-inflammatory ingredient with emerging evidence for its photoaging protection and beneficial effects on skin barrier and texture across all skin types.

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