Science
Mechanism of Action
This compound acts exclusively as a perfuming and fragrance agent, contributing its characteristic sweet, minty odor. Current research has not identified any specific mechanism of action through which it provides therapeutic or other cosmetic benefits to the skin beyond its aromatic properties.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
As an ingredient used for its fragrance properties rather than therapeutic activity, Isopulegyl Acetate is not typically 'dusted' in formulations for efficacy, so this analysis does not apply.
The Formula
Formulation
Stability
No specific data regarding optimal pH or stability parameters were found in the available research.
Safety
Safety Profile
The Research Institute for Fragrance Materials (RIFM) assessment found Isopulegyl Acetate negative for cytotoxicity and genotoxicity. However, it is identified as a skin sensitizer, with a No Expected Sensitization Induction Level (NESIL) of 2500 μg/cm2, determined via read-across data. Maximum acceptable concentrations vary by product category, with an example being 0.35% for face/body products applied with fingertips. Notably, human experience with an 8% solution did not demonstrate irritation or sensitization. While the Joint FAO/WHO Expert Committee on Food Additives (JECFA) deemed it safe as a flavoring agent and the FDA lists it as such, a comprehensive Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) report specifically for cosmetic use is absent, suggesting limited data for a full dermatological safety evaluation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Isopulegyl Acetate provides no demonstrated therapeutic benefits to the skin and carries a moderate risk of sensitization, making its inclusion in precision skincare formulations questionable.
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References
Sources