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ISOPROPYLIDENEGLYCERYL METHACRYLATE.

Avoid CAS 7098-80-8 / BINDING, FILM FORMING, NAIL CONDITIONING

Isopropylideneglyceryl Methacrylate is primarily a monomer precursor designed to undergo polymerization, forming larger polymeric structures such as poly(glycerol monomethacrylate). This foundational role positions it within materials science, contributing to the development of various specialized products, rather than direct topical skincare applications.

Summary

Monomer precursor Polymerizing agent

Science

Mechanism of Action

This compound functions as a monomer, initiating polymerization to yield diverse polymeric structures. For instance, selective hydrolysis of its acetal groups at low pH (e.g., pH 1 at 70 °C) can transform it into water-soluble poly(glycerol monomethacrylate). While the monomer itself lacks direct skin-benefiting mechanisms, its resulting methacrylate-based polymers, when integrated into specific matrices like wound dressings, have demonstrated the capacity to enhance macromolecule penetration across the stratum corneum, facilitating targeted drug delivery via polymer swelling.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As a water-immiscible, protected monomer precursor, Isopropylideneglyceryl Methacrylate exhibits instability under highly acidic conditions. Its acetal groups can undergo deprotection and subsequent hydrolysis at low pH, exemplified at pH 1 and 70 °C, leading to the formation of water-soluble poly(glycerol monomethacrylate). General methacrylate polymers are also susceptible to instabilities related to interactions with plasticizers or pigments, and potential issues with incomplete film formation during coating processes.

Conflicts

  • Low pH environments (can cause deprotection/hydrolysis)
  • Skin contact (due to sensitizing potential, particularly in products not designed for skin contact)

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that methacrylate ester monomers, including Isopropylideneglyceryl Methacrylate, are safe specifically for use in nail enhancement products, provided strict measures are taken to avoid skin contact. This critical restriction is due to the inherent sensitizing potential of methacrylates. GHS classifications further identify this ingredient with hazard statements indicating 'Causes skin irritation' (H315), 'Causes serious eye damage' (H318), 'Causes serious eye irritation' (H319), and 'May cause respiratory irritation' (H335). It is listed as an active REACH Registered Substance by ECHA.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its documented high irritancy, significant sensitizing potential upon skin contact, and its primary function as an industrial polymer precursor without direct cosmetic benefits, Isopropylideneglyceryl Methacrylate is unsuitable for topical precision skincare formulations.

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