Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER.

Avoid CAS 1675-54-3 / NOT REPORTED

This compound, also known as Bisphenol A diglycidyl ether (BADGE), is primarily utilized in industrial applications like epoxy resins. While identified as a PPARγ inhibitor, it is chiefly recognized as a standardized chemical allergen and a suspected endocrine disruptor.

Summary

Science

Mechanism of Action

In biochemical contexts, Isopropylidenediphenol Diglycidyl Ether functions as a PPARγ inhibitor, impeding adipogenesis induced by rosiglitazone and insulin. However, its primary interaction upon direct skin contact is as a standardized chemical allergen, triggering cellular immune responses and increased histamine release, with no established beneficial mechanisms for typical skin concerns.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

This compound is not typically found in cosmetic formulations and is primarily an industrial chemical. Its known hazardous classifications and allergenic potential preclude its use as an intentionally 'dusted' ingredient in skincare.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

It is oil-soluble. In aqueous environments, particularly with water content exceeding 40% v/v, it undergoes hydrolysis, forming derivatives such as BADGE·H2O and BADGE·2H2O, which can lead to a decrease in its concentration over time.

Conflicts

  • water (due to hydrolysis)
  • hydrochloric acid (forms chlorohydrins)
  • proteins
  • nucleophilic side-chains of amino acids

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has not evaluated this ingredient. It carries a high risk of sensitization and irritation, classified as 'Skin Irrit. 2' and 'Skin Sens. 1', and is identified as a standardized chemical allergen. Bisphenol A diglycidyl ether (BADGE) and its derivatives are considered suspected endocrine disruptors, with hydrolysis capable of releasing Bisphenol A (BPA), also a suspected endocrine disruptor. The European Food Safety Authority (EFSA) has established a Tolerable Daily Intake (TDI) of 0.15 mg/kg body weight for BADGE and its primary hydrolysis products (BADGE·H2O, BADGE·2H2O). Initial genotoxicity concerns were later disproven in in vivo studies.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

This industrial chemical is a known skin irritant and sensitizer, a suspected endocrine disruptor, and has no established skincare benefits, rendering it unsuitable for cosmetic formulations.

Related

Similar Ingredients

Finding similar ingredients…