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Moumoujus

ISOPROPYL THIOXANTHONE.

Avoid CAS 5495-84-1 / SKIN CONDITIONING

Isopropyl Thioxanthone (ITX) is an organic compound predominantly employed as a photoinitiator in industrial applications, particularly for UV-curing processes. While theorized to offer UV filtration and skin conditioning benefits in cosmetic formulations, its direct safety and efficacy for skincare remain critically under-investigated.

Summary

skin conditioning uv filter

Science

Mechanism of Action

Functioning primarily as a photoinitiator, Isopropyl Thioxanthone absorbs ultraviolet light within the 250-400 nm spectrum to initiate polymerization in various industrial materials. In theoretical cosmetic contexts, it is suggested to act as a UV filter, potentially shielding the skin from harmful radiation and contributing to product stability. Preliminary research also indicates potential anti-estrogenic and anti-androgenic properties, though these are not explored for cosmetic application.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding dusting potential in cosmetic applications for Isopropyl Thioxanthone is available.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient exhibits chemical stability under standard ambient conditions (room temperature) but is sensitive to light exposure. It should be protected from direct light and avoid contact with oxidizing agents to maintain its integrity.

Conflicts

  • oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Unknown

Isopropyl Thioxanthone (ITX) is primarily utilized in industrial contexts and has not undergone extensive safety evaluation as a direct skincare ingredient. The European Food Safety Authority (EFSA) has indicated no genotoxic effects, however, the US Environmental Protection Agency (USEPA) is actively examining its potential toxicity, particularly concerning migration from food packaging. GHS classifications highlight significant concerns: it is harmful if swallowed, suspected of damaging fertility or the unborn child, and is very toxic to aquatic life with long-lasting effects. While animal models did not show harmful effects from skin contact, exposure to open cuts, abraded, or irritated skin is contraindicated. ITX is also identified as an irritant to skin and a severe eye irritant. Its comprehensive toxicological profile for cosmetic applications remains largely undetermined.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the significant safety concerns, including potential reproductive toxicity and notable irritancy, combined with a profound lack of cosmetic-specific safety and efficacy data, Isopropyl Thioxanthone is strongly not recommended for skincare formulations.

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