Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ISOPROPYL PHENYLACETALDEHYDE.

Questionable CAS 4395-92-0 / PERFUMING

Isopropyl Phenylacetaldehyde is an aromatic compound primarily incorporated into cosmetic formulations for its distinct woody, citrus, and floral fragrance profile. Beyond its significant olfactory contributions, it may also provide a stabilizing effect to complex fragrance blends. Due to its potential for irritation and skin sensitization with prolonged exposure, its inclusion in precision skincare requires careful consideration.

Summary

Fragrance Ingredient Fragrance Stabilizer

Science

Mechanism of Action

This compound primarily functions as a fragrance ingredient, imparting a specific olfactive profile characterized by woody, citrus, and floral notes. It is also observed to offer a stabilizing effect to fragrance compositions, aiding in the preservation of their aromatic integrity over time. Direct mechanisms for skin benefit are not indicated.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

For optimal preservation, Isopropyl Phenylacetaldehyde requires storage in a tightly sealed container, protected from direct sunlight, excessive heat, and moisture. A dry, well-ventilated environment is crucial to prevent deterioration. It is a flammable substance, with a flash point measured at 95°C (203°F).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Research Institute for Fragrance Materials (RIFM) Expert Panel for Fragrance Safety has assessed p-isopropyl phenylacetaldehyde (CAS 4395-92-0), concluding that existing information supports its use as described in their safety assessment. This evaluation encompassed genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. While a BlueScreen assay showed positive results for cytotoxicity and genotoxicity, read-across data from analogous materials suggest that it is not anticipated to be genotoxic. A No Expected Sensitization Induction Level (NESIL) of 1100 μg/cm2 has been established for skin sensitization. It is important to note that prolonged exposure to p-isopropyl phenylacetaldehyde has been observed to cause irritation to both skin and eyes.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Isopropyl Phenylacetaldehyde serves as a fragrance and fragrance stabilizer, but its lack of direct skin benefits and potential for moderate irritation and sensitization make its inclusion in precision skincare questionable for skin health-focused formulations.

Related

Similar Ingredients

Finding similar ingredients…