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Moumoujus

ISOPROPYL NICOTINATE.

Avoid CAS 553-60-6 / SKIN CONDITIONING

Isopropyl nicotinate functions as a topical vasodilator, undergoing hydrolysis in the epidermis to its active form, nicotinic acid. This process stimulates localized blood flow, resulting in a characteristic and often pronounced skin reddening. It is primarily utilized for its stimulating and microcirculation-enhancing effects.

Summary

Vasodilator Skin-conditioning

Science

Mechanism of Action

Upon topical application, Isopropyl Nicotinate readily penetrates the epidermis where it is hydrolyzed into its active metabolite, nicotinic acid. This active form selectively activates the G protein-coupled receptor 109A (GPR109A), also known as HCAR2, located on epidermal cells such as keratinocytes and Langerhans cells. This receptor activation initiates the arachidonic acid cascade, leading to the synthesis and release of prostaglandins, specifically Prostaglandin D2 (PGD2) and Prostaglandin E2 (PGE2). These prostaglandins subsequently act on vascular smooth muscle, inducing vasodilation, increasing localized blood flow, and manifesting as visible skin reddening (erythema).

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The primary degradation pathway involves hydrolysis of the ester bond, yielding nicotinic acid and isopropanol, a process accelerated by both acidic and basic conditions. To optimize stability, formulations should be buffered to a slightly acidic to neutral pH range. Elevated temperatures significantly accelerate degradation, necessitating storage at controlled room temperature and protection from excessive heat. Light exposure may also contribute to degradation, suggesting the use of opaque or amber-colored packaging.

Conflicts

  • acids
  • bases
  • metal ions

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Isopropyl Nicotinate is registered in the FDA's Global Substance Registration System. Its EPA TSCA Commercial Activity Status is 'INACTIVE'. According to GHS classification, it is categorized as causing skin irritation (H315), serious eye irritation (H319), and potentially respiratory irritation (H335).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its mechanism inducing significant skin reddening and high irritancy classification, Isopropyl Nicotinate is generally recommended to be avoided in skincare formulations for broad consumer use.

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