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Ingredient directory

Isopropyl-methylcyclohexadiene

ISOPROPYL-METHYLCYCLOHEXADIENE, also known as gamma-Terpinene, is a naturally occurring monoterpene found in the essential oils of plants such as tea tree and lemon. It is recognized for its broad-spectrum biological activities including antimicrobial and antioxidant properties. This compound also serves as a perfuming agent in various cosmetic formulations.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

antimicrobial antibacterial antifungal antioxidant perfuming soothing anti-inflammatory sebum regulation pore size reduction

Science

Mechanism of Action

Gamma-Terpinene exhibits antimicrobial action against bacteria, viruses, and fungi on the skin. It acts as an antioxidant, helping to neutralize free radicals and mitigate oxidative stress. Evidence suggests it may contribute to anti-inflammatory effects and, when derived from lemon oil, is associated with anti-comedogenic benefits through the regulation of sebum production and reduction of pore size.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The pH stability of gamma-Terpinene has not been definitively determined. It is a reactive substance with a risk of ignition when heated, and its vapors can form explosive mixtures with air. It demonstrates violent reactions with strong oxidizers.

Conflicts

  • strong oxidizers

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has not provided a direct safety assessment for isolated gamma-Terpinene due to insufficient data. However, the Scientific Committee on Consumer Safety (SCCS) has identified gamma-Terpinene as a 'Suspected skin sensitiser.' Related reaction masses are classified with warnings for skin irritation (H315) and potential allergic skin reactions (H317). Undiluted essential oils containing gamma-Terpinene, particularly if oxidized, can lead to irritant and allergic responses on the skin.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Low

Our Assessment

Verdict

Questionable

While offering potential benefits in antimicrobial and antioxidant activities, ISOPROPYL-METHYLCYCLOHEXADIENE carries significant safety concerns, including a 'Suspected skin sensitiser' classification and medium irritancy, rendering it questionable for precision skincare formulations without comprehensive safety and efficacy data.

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References

Sources

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