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Moumoujus

ISOPROPYL ALCOHOL.

Questionable CAS 67-63-0 / ANTIFOAMING, PERFUMING, SOLVENT, VISCOSITY CONTROLLING

Isopropyl Alcohol is a volatile organic compound recognized for its potent antimicrobial and solvent capabilities. It effectively dissolves skin oils and enhances the absorption of other ingredients, making it useful in targeted skincare for conditions like acne. However, its high irritancy and drying potential necessitate extremely careful formulation and application.

Summary

Antifoaming Perfuming Solvent Viscosity controlling Astringent Antimicrobial Penetration enhancer

Science

Mechanism of Action

Isopropyl alcohol's mechanism involves denaturing microbial proteins and dissolving cellular lipids, which disrupts the cell membranes of microorganisms, leading to their death. On the skin, it functions as an effective solvent, breaking down surface oil, sebum, and debris. It also acts as a penetration enhancer, facilitating the absorption of other active ingredients.

Research

Clinical Evidence

High confidence
Effective range 60–91.3%
Optimal

N/A

Key findings

  1. 01 Demonstrates efficacy in concentrations between 60% and 90% for eradicating a broad spectrum of germs and bacteria associated with acne.
  2. 02 Concentrations of 70% to 91.3% (vol/vol) are recognized by the FDA as safe and effective for patient preoperative skin preparation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for formulation stability was identified in the available data.

Synergies

  • Enhances absorption of other active ingredients

Conflicts

  • Compromised skin (open wounds, sunburned, windburned, dry, or irritated skin)
  • High concentrations can disrupt the skin barrier
  • Can diminish the efficacy of moisturizing ingredients if not carefully balanced in formulation

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Isopropyl Alcohol 'safe with restrictions'. While high concentrations (e.g., 60-90% for antiseptic uses) are effective for specific applications, lower doses are generally recommended for cosmetic skincare due to significant drying and irritating effects. Pure isopropyl alcohol is toxic if absorbed systemically and should never be used directly on the skin. It must be avoided on skin with open wounds, sunburn, windburn, dryness, or irritation.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Low

Our Assessment

Verdict

Questionable

While effective as an antimicrobial solvent for specific targeted applications, Isopropyl Alcohol's high irritancy and drying potential necessitate cautious and precise formulation, limiting its broad utility in general skincare.

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