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ISOPROPANOLAMINE.

Valuable CAS 78-96-6 / BUFFERING

Isopropanolamine is an alkanolamine primarily utilized in skincare formulations for its foundational role as a pH adjuster and neutralizing agent. It also functions as an effective emulsifier, supporting the stability of water and oil blends, and can act as a co-solvent to ensure product uniformity.

pH Adjuster Emulsifier Co-solvent

Science

As a weak base, Isopropanolamine precisely neutralizes acidic components within a cosmetic formulation, generating salts and water to stabilize pH. Its ability to reduce surface tension allows for the creation and maintenance of stable emulsions, seamlessly integrating oil and water phases. Additionally, it serves as a co-solvent, enhancing the smooth dispersion of diverse ingredients.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This basic compound generally remains stable under typical conditions but may show oxidation and discoloration with extended exposure to air or iron. Formulations utilizing monoisopropanolamine may exhibit improved color and heat stability compared to those with conventional ethanolamines. It is hygroscopic, meaning it attracts and absorbs moisture from the atmosphere.

Conflicts

  • N-nitrosating agents (due to potential nitrosamine formation)
  • Strong acids
  • Strong oxidizing agents
  • Isocyanates
  • Halogenated organics
  • Peroxides
  • Acidic phenols
  • Epoxides
  • Anhydrides
  • Acid halides
  • Strong reducing agents (risk of flammable hydrogen generation)

Safety

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Low

The CIR Expert Panel deems Isopropanolamine safe for use in cosmetics, provided it is not incorporated into products containing N-nitrosating agents to prevent the formation of potentially carcinogenic nitrosamines. The SCCS in Europe similarly approves its use under specific conditions outlined in Annex III of the EC Cosmetics Regulation. The FDA allows cosmetic ingredient use without pre-market approval if the final product is safe.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Isopropanolamine is a valuable formulation aid, critical for pH adjustment, emulsification, and co-solvency in various cosmetic products, demonstrating a low sensitization risk under approved usage restrictions.


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