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Moumoujus

ISOPHORONE DIISOCYANATE.

Avoid CAS 4098-71-9 / FILM FORMING

Isophorone Diisocyanate (IPDI) is a highly reactive chemical primarily utilized in industrial settings for the synthesis of polyurethanes. It is explicitly categorized as a hazardous substance, known to cause severe irritation, corrosion, and allergic sensitization upon skin contact.

Summary

Science

Mechanism of Action

Upon dermal exposure, IPDI acts as a potent corrosive agent, inducing direct tissue damage and profound irritation. Furthermore, its interaction can trigger immune-mediated responses, manifesting as skin sensitization and subsequent allergic reactions.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0%

Isophorone Diisocyanate is a highly hazardous substance explicitly prohibited for direct inclusion in cosmetic formulations. Its presence at any concentration in skincare products would constitute a significant safety risk.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

IPDI exhibits extreme reactivity, particularly with water, undergoing rapid hydrolysis. Its instability extends to a wide array of common formulation components, including acids, alcohols, amines, bases, and phenols, often resulting in violent or explosive reactions.

Conflicts

  • Water
  • Alcohols
  • Amines
  • Bases
  • Acids
  • Amides
  • Phenols
  • Mercaptans
  • Urethanes
  • Ureas
  • Plastics
  • Rubber

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Sensitization risk High

Isophorone Diisocyanate is classified as a hazardous chemical due to its inherent toxicity and reactivity. It is severely irritating and corrosive to both skin and eyes, with the potential for permanent eye damage. Furthermore, it is a recognized skin sensitizer, meaning repeated exposure can induce severe allergic contact dermatitis. The Cosmetic Ingredient Review (CIR) Expert Panel has underscored that diisocyanate monomers should be entirely absent from cosmetic ingredients derived from polyurethanes, confirming its unsuitability for direct cosmetic application.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Isophorone Diisocyanate is a hazardous industrial chemical with severe corrosive, irritating, and sensitizing properties, rendering it completely unsuitable and unsafe for any cosmetic application.

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