Science
Mechanism of Action
Upon cutaneous exposure, Isophorone Diamine functions as a potent irritant and sensitizer. Its inherent corrosivity and alkalinity instigate an adverse inflammatory response in the skin, clinically manifesting as erythema, pruritus, and the potential for contact dermatitis or allergic reactions.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Isophorone Diamine is not typically incorporated or 'dusted' into cosmetic formulations, given its primary industrial applications as a curing agent and its documented severe irritancy and corrosive nature on skin.
The Formula
Formulation
Stability
The compound demonstrates stability under standard environmental conditions. A 10g/l solution in water at 20℃ registers a notably alkaline pH of 11.6.
Conflicts
- strong oxidizing agents
- acids
- isocyanates
- halogenated organics
- peroxides
- phenols (acidic)
- epoxides
- anhydrides
- acid halides
- carbon dioxide (from air, forms deposits)
- metals (may evolve flammable hydrogen gas)
Safety
Safety Profile
Isophorone Diamine is classified as a strong sensitizer and corrosive agent to the skin, capable of inducing irritation, redness, itching, dermatitis, and severe allergic reactions upon contact. It presents toxicity risks via both inhalation and skin absorption. While its polyurethane derivatives have undergone CIR review and are deemed safe when non-sensitizing, there is no direct CIR assessment for Isophorone Diamine as a standalone cosmetic ingredient for direct topical application. It is primarily listed in FDA regulations (21 CFR 175.105) for industrial applications such as food-contact adhesives.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its potent corrosive, sensitizing, and highly irritating properties, coupled with a lack of safety assessment for direct skin application, Isophorone Diamine is unsuitable and should be strictly avoided in skincare formulations.
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References
Sources