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Moumoujus

ISOMENTHONE.

Optional CAS 491-07-6 / PERFUMING

Isomenthone is a naturally occurring monoterpene ketone recognized for its refreshing and minty cooling properties. Primarily utilized for its sensory contributions, it functions as a perfuming and flavoring agent in diverse product formulations.

Summary

perfuming cooling effect

Science

Mechanism of Action

This compound delivers a refreshing and distinct minty cooling sensation when incorporated into compositions, primarily acting on sensory receptors rather than offering direct dermatological benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 At an 8% concentration in petrolatum, isomenthone (and racemic menthone) produced no evidence of skin irritation in human subjects.
  2. 02 An in vitro assessment on reconstructed human epidermis demonstrated that a mixture containing 23.5% isomenthone (within a 76% menthone mix) led to a mean tissue viability of 10.4% after 15 minutes, classifying the combined chemicals as skin irritants.

Transparency

Dusting Analysis

Not commonly dusted

No data available to indicate common dusting practices or specific dusting thresholds for isomenthone.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Isomenthone exhibits stability under typical ambient storage and handling conditions. It maintains its integrity in perfumes and various functional bases. As a hygroscopic substance, storage in a refrigerator under an inert atmosphere is recommended to preserve stability.

Conflicts

  • strong oxidizer
  • strong oxidizing agents
  • strong reducing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
8%
Sensitization risk Moderate

The European Chemicals Agency (ECHA) classifies isomenthone with hazard statements H315 (Causes skin irritation) and H317 (May cause an allergic skin reaction). However, the Expert Panel for Fragrance Safety (RIFM) has concluded that menthone, encompassing d,l-isomenthone, is safe for use within its safety assessment, specifying a No Expected Sensitization Induction Level (NESIL) of 10000 µg/cm² for skin sensitization. It is registered in the FDA Global Substance Registration System (GSRS) and recognized as a flavoring agent.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Isomenthone serves as an optional ingredient in precision skincare, primarily for its sensory cooling and perfuming attributes, provided it is formulated carefully below the 8% concentration to mitigate potential irritation as indicated by human patch test data.

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