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Moumoujus

ISOEUGENYL ACETATE.

Questionable CAS 93-29-8 / PERFUMING

Isoeugenyl Acetate is a fragrance ingredient derived from Isoeugenol, commonly found in perfumes and cosmetics. While it possesses antibacterial and antifungal properties, it is primarily recognized for its aromatic profile and its potential to be hydrolyzed into Isoeugenol on the skin, a known sensitizer.

Summary

Fragrance Antibacterial Antifungal

Science

Mechanism of Action

This compound is an acetylated derivative of Isoeugenol, which is likely to undergo hydrolysis by skin enzymes, converting it back into Isoeugenol upon topical application. Isoeugenol is a known skin sensitizer, whose mechanism involves the formation of reactive intermediates through enzymatic action or oxidation. These intermediates can then covalently bind to skin proteins, initiating a sensitization response. Additionally, Isoeugenyl Acetate exhibits mild antibacterial and antifungal properties.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

0.9%

Key findings

  1. 01 Identified as the maximum acceptable concentration in a finished perfume by IFRA 51 to minimize sensitization risk.
  2. 02 Demonstrated a No Expected Sensitization Induction Level (NESIL) for skin sensitization.
  3. 03 Did not elicit a sensitizing response in a murine local lymph node assay (LLNA) up to this concentration.
  4. 04 No sensitization reactions were observed in human maximization tests at this concentration.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.9%
Red flag below
0.9%

Isoeugenyl Acetate is considered a regulated allergen in Europe due to its potential for skin sensitization. The International Fragrance Association (IFRA) has established a maximum acceptable concentration of 0.9% in finished perfumes to ensure safe use, making concentrations above this a red flag.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The ingredient maintains stability for at least 2 years post-receipt when stored at +4°C. Protection from both light and moisture is advised to preserve its integrity.

Conflicts

  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.9%
Sensitization risk Moderate

RIFM assessments indicate a potential for skin sensitization in a small subset of the population. Consequently, IFRA 51 mandates a maximum concentration of 0.9% in finished perfumes. It is classified as a regulated allergen in Europe. The FDA has granted it Generally Recognized As Safe (GRAS) status, specifically within the context of food additives.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Due to its potential for hydrolysis into a known sensitizer and its classification as a regulated allergen, Isoeugenyl Acetate's inclusion in precision skincare formulations is questionable, despite established safe use limits for fragrance applications.

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