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ISOCYCLOCITRAL.

Questionable CAS 1335-66-6 / 1423-46-7 / 67634-07-5 / PERFUMING

Isocyclocitral is an aromatic aldehyde primarily valued for its distinct fragrance profile, characterized by powerful, diffusive foliage-green, earthy, and wet notes, often likened to a 'flower-shop' scent. It is incorporated into various personal care formulations for its olfactive contribution.

Fragrance

Science

Currently, no specific mechanism of action offering direct skincare benefits has been identified for Isocyclocitral. Its function within cosmetic formulations is solely attributed to its fragrant properties.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

This ingredient is not associated with 'dusting' in the context of active skincare ingredients, as it provides no direct skin benefits.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Isocyclocitral exhibits good stability under normal formulation conditions. As an aldehyde, it may react in alcoholic solutions to form diethylacetals, though this typically does not significantly alter its aromatic profile.


Safety

CIR Status
Not reviewed
Sensitization risk Moderate

Safety assessments by the Research Institute for Fragrance Materials (RIFM) indicate that Isocyclocitral carries a potential for skin sensitization in a subset of individuals upon repeated contact, leading to temporary reactions such as redness or itching. The International Fragrance Association (IFRA) has established quantitative safe use standards based on product categories due to this dermal sensitization risk. For example, IFRA Cat. 2 products (e.g., deodorants) have a limit of 0.16%, while Cat. 4 products (e.g., face creams) are limited to 3%. GHS classification further indicates it may cause an allergic skin reaction (Skin Sens. 1), causes skin irritation (Skin Irrit. 2), and causes serious eye irritation (Eye Irrit. 2).


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

While widely utilized for its unique fragrance profile in various personal care products, Isocyclocitral offers no identified benefits for skin health and presents a moderate risk of skin sensitization and irritation, making its inclusion in precision skincare focused on efficacy highly questionable.


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