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Moumoujus

ISOBUTYL FURYLPROPIONATE.

Questionable CAS 105-01-1 / PERFUMING

Isobutyl Furylpropionate is an ester primarily known for its role as a perfuming and flavoring agent. While some human data suggests a low risk of irritation at 2% concentration, comprehensive toxicological concerns regarding its furan ring structure raise questions about its broader safety profile, particularly in skincare applications.

Summary

Perfuming Agent

Science

Mechanism of Action

The precise mechanism of action on the skin is not elucidated in current research. Given its classification as a perfuming agent, its primary interaction with the skin would be olfactory, providing a fragrance.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is not commonly featured in precision skincare formulations or consumer marketing, and therefore, the concept of 'dusting' does not apply.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As an ester, Isobutyl Furylpropionate is susceptible to hydrolysis when exposed to water, which can lead to its degradation into its constituent alcohol and acid. For optimal stability, it requires storage in a cool, dry environment, meticulously sealed, and shielded from light and heat.

Conflicts

  • strong oxidizing acids (can trigger vigorous, exothermic reactions leading to ignition)
  • caustic solutions (generate heat)
  • alkali metals
  • hydrides
  • certain plastics

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
6%
Sensitization risk Low

The Joint FAO/WHO Expert Committee on Food Additives (JECFA) could not complete its assessment due to unresolved toxicological questions, including concerns regarding the furan ring structure, metabolism, covalent binding, and potential genotoxicity. Although ECHA GHS classifications indicate that 88.8% of reports do not meet hazard criteria, 11.2% classify it as acutely toxic if swallowed or in contact with skin. While human patch tests at 2% showed no irritation or sensitization, the lack of comprehensive safety reviews by bodies like CIR, combined with the JECFA concerns, suggests a cautious approach. The FDA's ambiguous stance on its food additive status does not clarify its safety for cosmetic use; the cited maximum concentration of 6% pertains to fragrance concentrates, not necessarily direct cosmetic application limits.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low (at 2% concentration)
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Due to unresolved toxicological concerns from expert committees and a complete absence of demonstrated skin benefits, this ingredient's inclusion in precision skincare formulations is not recommended.

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