Science
Mechanism of Action
Isatin and its derivatives are known to exhibit diverse biological activities, including antioxidant and anti-inflammatory effects. It also functions as a monoamine oxidase inhibitor. Of note for skin, a specific precursor glycoside of isatin has been linked to an increase in skin blood flow.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Isatin demonstrates stability and should be stored below +30°C. A 1.9 g/L solution in water at 20°C exhibits a neutral pH of 7.
Conflicts
- strong acids
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not specifically evaluated Isatin for use in skincare, and no maximum concentration has been established. While cosmetic ingredients generally do not require FDA pre-market approval in the U.S., Isatin is listed in COSMILE Europe as a hair dyeing ingredient, implying potential regulatory conditions within Annex III for this application in the EU.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to a lack of dedicated clinical studies, an unreviewed safety profile for cosmetic use, and unknown skin compatibility metrics, there is insufficient data to establish Isatin as a key active for targeted skincare benefits.
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References
Sources