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Moumoujus

IODOFORM.

Avoid CAS 75-47-8 / ANTIMICROBIAL

Iodoform is a historically recognized antiseptic primarily utilized in medical and veterinary fields for wound care and dental applications. Its efficacy stems from its potential antimicrobial properties and ability to chemically debride necrotic tissue. However, it is not typically found in cosmetic formulations due to its adverse dermatological profile.

Summary

Antimicrobial Chemical Debriding Agent Antiseptic

Science

Mechanism of Action

Iodoform exerts its effects primarily through the gradual release of elemental iodine, which oxidizes and denatures bacterial proteins, thereby providing antimicrobial action. Furthermore, it demonstrates lytic activity on collagen fibers, facilitating the chemical debridement of necrotic tissue crucial for effective wound healing. At elevated concentrations, iodoform may also exhibit cytotoxic effects on inflammatory cells.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a clinical study, iodoform gauze demonstrated superior efficacy in debriding necrotic tissue from pressure ulcers compared to conventional ointments, achieving complete debridement in over 60% of wounds within two weeks. This was attributed to its collagen fibrinolytic activity.

Transparency

Dusting Analysis

Not commonly dusted

Iodoform is exclusively used in medical or veterinary applications as an antiseptic and is not recognized as a cosmetic ingredient. Therefore, the concept of 'dusting' in cosmetic formulation is not applicable to this compound.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Iodoform is chemically reactive in free-radical reactions and decomposes at high temperatures, specifically 204 °C (400 °F), with the evolution of iodine.

Conflicts

  • mercuric oxide
  • calomel
  • silver nitrate
  • tannin
  • balsam peru
  • lithium
  • acetone

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Iodoform is classified as an irritant, capable of causing skin, serious eye, and potential respiratory irritation. Exposure can lead to dermatological side effects, including the triggering of dermatitis herpetiformis (DH) flares in susceptible individuals. While rare with current medical uses, toxicity can manifest as neurotoxicity and systemic symptoms. It is not typically found in cosmetic skincare products; products making therapeutic claims using iodoform would be classified as drugs and require FDA approval.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a significant irritant, potential to trigger severe dermatological side effects like dermatitis herpetiformis, lack of cosmetic safety review, and primary use as a medical drug, Iodoform is contraindicated for precision skincare formulations.

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