Science
Mechanism of Action
This ingredient is an endogenous plant substance, a conjugate of indole-3-acetic acid and L-glutamic acid, which contributes to plant growth regulation and environmental stress protection. It exhibits antioxidant properties in botanical contexts. Although glutamic acid, its component, is known for humectant, skin-conditioning, and anti-inflammatory properties in human skin, the precise mechanisms of action for the conjugated Indoleacetyl Glutamic Acid on human skin are not yet thoroughly delineated.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Specific stability data for Indoleacetyl Glutamic Acid is unavailable. However, its glutamic acid component can slowly convert to pyrrolidonecarboxylic acid at room temperature, a process accelerated at pH 2-3 and elevated temperatures.
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) Expert Panel deemed alpha-amino acids, including glutamic acid, safe for cosmetic use, and glutamic acid has been used as a negative control in sensitization studies, Indoleacetyl Glutamic Acid itself lacks a dedicated CIR or SCCS safety assessment. It does possess a UNII from the FDA's Global Substance Registration System, indicating its recognition as a substance.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Indoleacetyl Glutamic Acid, a plant-derived antioxidant, shows promise due to its composition, but currently lacks sufficient specific research data on its efficacy and safety when applied to human skin to provide a definitive cosmetic rating.
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