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Moumoujus

IMIDAZOLE.

Avoid CAS 288-32-4 / BUFFERING

Imidazole is a fundamental organic compound recognized for its amphoteric nature, enabling it to act as both an acid and a base. Its primary utility in cosmetic formulations is as a buffering agent, helping to maintain the pH stability of a product.

Summary

Buffering agent

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 9
0 7 14

Stability

Highly polar and entirely water-soluble, Imidazole exhibits amphoteric properties with a pKa value typically ranging from 6.95 to 7.1. It demonstrates pronounced activity and buffering capacity within the pH range of 5 to 9. An aqueous solution of Imidazole (38 g/L at 20°C) has a pH of 10.5.

Conflicts

  • Corrosive to skin and eyes
  • Acid addition salt forms of imidazole derivatives can adversely affect retinol stability

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel and the Scientific Committee on Consumer Safety (SCCS) have not specifically evaluated Imidazole (the parent compound) for its safety as a cosmetic ingredient. The U.S. Food and Drug Administration (FDA) classifies raw Imidazole as corrosive, harmful if swallowed, and capable of causing severe skin burns and eye damage, though it notes its use as a buffering agent in cosmetics.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

While recognized for its buffering capabilities, Imidazole is classified as a corrosive chemical with the potential to cause severe skin burns and eye damage, and it lacks specific safety reviews for cosmetic application, making it unsuitable for direct topical use.

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