Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HYPOCHOERIS RADICATA FLOWER EXTRACT.

Valuable / SKIN CONDITIONING

This botanical extract is derived from the flower of Hypochoeris radicata, a plant recognized for its significant anti-inflammatory and antioxidant capabilities. It actively calms the skin by targeting key inflammatory pathways and neutralizing free radicals, making it a promising ingredient for soothing stressed complexions.

Summary

Anti-inflammatory Antioxidant Soothing Wound Healing (potential) Antibacterial (potential)

Science

Mechanism of Action

Hypochoeris Radicata Flower Extract demonstrates its anti-inflammatory effects by inhibiting the generation of nitric oxide (NO) and by suppressing the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, ERK, and JNK. This mechanism leads to a reduction in pro-inflammatory molecules (iNOS, PGE2, COX-2) and cytokines (TNF-α, IL-1ß, IL-6). The extract also functions as a natural antioxidant, providing protection against oxidative stress through its rich content of compounds including luteolins, quercetin, naringenin, catechin, other phenolic compounds, and various flavonoids.

Research

Clinical Evidence

Medium confidence
Effective range 12.5–50%
Optimal

N/A

Key findings

  1. 01 In *in vitro* studies on LPS-stimulated RAW 264.7 macrophages, ethanol extracts at concentrations up to 500 ug/mL demonstrated effective inhibition of nitric oxide (NO) generation without any observed cellular toxicity.
  2. 02 An ethyl acetate fraction (HRF-EA) of the flower extract, at concentrations ranging from 12.5 to 50 µg/mL, significantly inhibited the production of a spectrum of pro-inflammatory molecules (NO, iNOS, PGE2, COX-2) and cytokines (TNF-α, IL-1ß, IL-6). This anti-inflammatory action was correlated with a concentration-dependent suppression of p38, ERK, and JNK MAPK phosphorylation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Conflicts

  • Individuals with allergies to the Asteraceae family

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Hypochoeris radicata extracts have shown no toxic effects on cells in *in vitro* studies. While the plant generally exhibits low severity poison characteristics, there is a risk of allergic reactions in individuals sensitive to plants from the Asteraceae family. This ingredient has not been reviewed by the CIR and is not on its current or draft priority lists.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hypochoeris Radicata Flower Extract is a valuable botanical ingredient, demonstrating potent anti-inflammatory and antioxidant activities *in vitro* that can soothe and protect skin, though individuals with Asteraceae allergies should exercise caution.

Related

Similar Ingredients

Finding similar ingredients…

References

Sources