Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HYPOCHOERIS RADICATA EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Derived from the Hairy Cat's Ear plant, Hypochoeris Radicata Extract is a multi-functional ingredient demonstrating significant anti-inflammatory and antioxidant capabilities. It works to soothe irritated skin by targeting key inflammatory pathways while protecting against oxidative stress.

Summary

Skin Conditioning Anti-inflammatory Antioxidant Soothing

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by inhibiting the production of various pro-inflammatory molecules, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2). It also suppresses inflammatory cytokines such as TNF-α, IL-1ß, and IL-6, and deactivates MAPK signaling pathways (p38, ERK, JNK). Rich in phenolic and flavonoid compounds, the extract provides potent antioxidant activity through free radical scavenging, ferrous ion chelation, and enhancing reducing power, thereby protecting skin cells from oxidative damage.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An ethyl acetate fraction of Hypochoeris radicata extract (HRF-EA) significantly inhibited the production of pro-inflammatory molecules (NO, iNOS, PGE2, COX-2) and cytokines (TNF-α, IL-1ß, IL-6) in LPS-stimulated RAW 264.7 cells in a concentration-dependent manner. Specifically, HRF-EA at 100 µg/mL, 200 µg/mL, and 400 µg/mL decreased NO production by 35%, 51%, and 82%, respectively.
  2. 02 Methanolic extracts of leaf and root at 250 µg/mL showed significant scavenging activity against DPPH free radicals (97.99% for leaf and 96.44% for root). At higher concentrations, such as 5000 µg/mL, it exhibited ferrous ions chelating activity (38.69% for leaf and 40.52% for root).

Transparency

Dusting Analysis

Not commonly dusted

No data is available to suggest this ingredient is commonly associated with cosmetic 'dusting' or to establish a dusting threshold.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH range for the extract's stability in cosmetic formulations is not specified. While the plant itself tolerates a broad soil pH range (3.9 to 8.6), this information does not directly apply to extract stability in a cosmetic matrix.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No direct safety assessments by regulatory bodies such as CIR, SCCS, or FDA have been found for Hypochoeris Radicata Extract. However, in vitro studies have shown no toxic effects on cells at tested concentrations, suggesting a favorable cellular safety profile.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hypochoeris Radicata Extract is a valuable botanical ingredient offering promising anti-inflammatory and antioxidant benefits for soothing and protecting sensitive or irritated skin, primarily supported by robust in vitro evidence.

Related

Similar Ingredients

Finding similar ingredients…