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Moumoujus

HYPOCHAERIS RADICATA FLOWER EXTRACT.

Insufficient Data / SKIN CONDITIONING

Hypochaeris Radicata Flower Extract is a botanical active distinguished by its potent anti-inflammatory and antioxidant capabilities. It precisely targets key inflammatory pathways and neutralizes free radicals, offering a multi-faceted approach to soothe and protect the skin.

Summary

Anti-inflammatory Antioxidant Soothing Redness Reduction

Science

Mechanism of Action

This extract exerts its anti-inflammatory action by downregulating pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). It also modulates the release of inflammatory cytokines, specifically tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1ß), and interleukin-6 (IL-6), within macrophage cells. Furthermore, it inhibits the phosphorylation of critical mitogen-activated protein kinases (MAPKs), including p38, ERK, and JNK, which are involved in inflammatory signaling cascades. Its antioxidant benefits stem from phytochemicals like phenolic compounds and flavonoids, such as luteolins, which effectively scavenge free radicals.

Research

Clinical Evidence

Medium confidence
Effective range 12.5–50%
Optimal

N/A

Key findings

  1. 01 In vitro studies on LPS-stimulated RAW 264.7 macrophage cells showed that an ethyl acetate fraction of Hypochaeris radicata flower extract (HRF-EA) significantly inhibited the production of various pro-inflammatory molecules (NO, iNOS, PGE2, COX-2) and cytokines (TNF-α, IL-1ß, IL-6) at concentrations of 12.5, 25, or 50 µg/mL. This effect was concentration-dependent and included the suppression of MAPK (p38, ERK, JNK) phosphorylation.
  2. 02 Further in vitro research confirmed the anti-inflammatory effect through inhibition of NO generation, with no observed cellular toxicity at high extract concentrations.
  3. 03 Methanolic leaf and root extracts demonstrated significant in vitro antioxidant activity across multiple assays (DPPH•, reducing power, ABTS•+, ferrous ion chelating activity), suggesting potent free radical scavenging capabilities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The plant itself tolerates a broad pH range from 3.9 to 8.6, reflecting its growth conditions rather than extract stability. However, the extract components are suggested to be both water and oil soluble, as preparations have been made with various solvents including 80% ethanol, ethyl acetate, and methanol.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

In vitro studies have shown no toxic effects on cells. However, the plant is known to have low severity poison characteristics when consumed in excess by horses. The ingredient may cause allergic reactions in individuals sensitive to the Asteraceae family. Currently, no specific safety assessments for cosmetic use have been conducted by CIR, SCCS, or FDA.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Hypochaeris Radicata Flower Extract shows promising in vitro anti-inflammatory and antioxidant activities; however, further human topical studies and comprehensive safety assessments are required for definitive cosmetic application.

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