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HYDROXYPROPYL METHYLCELLULOSE.

Valuable CAS 9004-65-3 / ANTISTATIC, BINDING, EMULSION STABILISING, FILM FORMING, SURFACTANT - CLEANSING, VISCOSITY CONTROLLING

Hydroxypropyl Methylcellulose (HPMC) is a versatile cellulose-derived polymer integral for enhancing product texture and skin hydration. It forms a breathable, non-greasy film on the skin, effectively reducing transepidermal water loss. In formulations, it acts as a crucial thickener and stabilizer, improving product consistency and feel.

Summary

Viscosity Controlling Film Forming Emulsion Stabilising Binding Antistatic Surfactant Humectant

Science

Mechanism of Action

HPMC functions on the skin primarily through its advanced hygroscopic properties and film-forming capabilities. It establishes a protective, non-occlusive barrier on the skin's surface, which actively binds water molecules, thereby diminishing transepidermal water loss and sustaining the skin's natural moisture equilibrium. As a multifunctional excipient, HPMC enhances cosmetic formulations by acting as a thickener, viscosity-increasing agent, emulsifier, and stabilizer. This improves the texture, consistency, and flow of products, facilitates controlled release of active ingredients, and contributes to a smooth, silky feel with improved spreadability.

Research

Clinical Evidence

High confidence
Effective range 0.1–4%
Optimal

For general cosmetic applications, concentrations typically range from 0.2% to 1.0%. Specifically, 0.2-0.5% is common for creams and lotions, while gels may utilize 1.0% or more to achieve desired viscosity and stability.

Key findings

  1. 01 Extensive skin tests confirm that concentrations between 0.1% and 2% are non-irritating and non-allergenic, even for sensitive, pregnant, and infant skin, ensuring long-term comfort.
  2. 02 Studies on topical gel formulations demonstrate optimal physical stability when HPMC is used as a gelling agent at concentrations of 1% to 4%, with specific applications at 1%, 1.5%, 2%, and 3%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 11
0 7 14

Stability

HPMC demonstrates high stability in aqueous solutions within a broad pH range of 3 to 11 and remains stable at room temperature. It exhibits thermal gelation, readily dissolving in cold water but forming a reversible gel upon heating (approximately 50–80°C) which solidifies and holds its shape, reverting to a solution upon cooling. It tolerates salt and alcohol, though high salt concentrations may slightly increase viscosity, and alcohol content exceeding 70% can reduce its solubility.

Conflicts

  • strong oxidizing agents
  • high concentrations of salts (can increase viscosity)
  • high concentrations of alcohol (>70% ethanol/IPA, can reduce solubility)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
100%
Pregnancy
Safe
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded HPMC is safe for use in cosmetics. Dermal irritation studies show it to be non-irritating to slightly irritating at concentrations up to 100%. It is globally recognized as non-toxic, non-irritating, and non-allergenic, with specific verification for use on sensitive, pregnant, and infant skin. While generally safe, excessive exposure may potentially lead to dryness or irritation, and a preliminary patch test is recommended for individual assessment.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Hydroxypropyl Methylcellulose is a highly versatile and well-tolerated polymer, providing significant benefits in enhancing product texture, ensuring stability, and supporting skin hydration through effective film-forming and moisture retention.

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