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HYDROXYPROPYL CHITOSAN.

Valuable CAS 84069-44-3 / FILM FORMING

Hydroxypropyl Chitosan is a highly soluble and versatile polymer derived from chitosan, meticulously engineered to enhance skin hydration and softness. It functions as a sophisticated film-forming and thickening agent, providing a protective barrier against moisture loss.

film forming thickening agent moisturizing moisture retaining carrier agent protective

Science

This modified chitosan derivative primarily works by creating a breathable, invisible film on the skin's surface. This film effectively reduces transepidermal water loss (TEWL), thereby absorbing and retaining moisture to maintain optimal skin hydration and alleviate dryness. Furthermore, it demonstrates utility as a carrier for other active ingredients. Its parent molecule, chitosan, suggests potential for additional benefits such as interaction with bacterial cell walls, support for wound healing via network formation, stimulation of collagen synthesis, and antioxidant, cleansing, and protective attributes.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 1 – 13
0 7 14

Stability

A key advantage of Hydroxypropyl Chitosan over unmodified chitosan is its solubility across a full pH range of 1 to 13, provided it has a degree of substitution (DS) of 0.40 or higher. This characteristic significantly broadens its applicability in diverse formulations and makes it suitable for creating stable gel and hydrogel products due to its favorable viscosity properties.

Synergies

  • Functions as an effective carrier for beneficial active ingredients, enhancing their delivery.

Conflicts

  • Divalent cations (e.g., from dicalcium phosphate dihydrate, calcium carbonate, and magnesium stearate), which can form coordination complexes with its amino groups (inferred from chitosan properties).
  • Anionic surfactants, with which it can form complexes, potentially altering surface-active properties.

Safety

CIR Status
Not reviewed
Sensitization risk Low

Hydroxypropyl Chitosan is rated with a low-risk score of 1, indicating its safety for use in cosmetic and skincare products. It shares a high degree of safety and natural biodegradability within the body, similar to its parent compound, chitosan. Chitosan itself is approved for cosmetic use by the FDA and the EU, and is not listed as a restricted substance. No specific SCCS opinion directly addressing Hydroxypropyl Chitosan was found in the available research.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Hydroxypropyl Chitosan is a valuable, multi-functional ingredient offering broad pH stability, effective skin hydration through film formation, and excellent compatibility across all skin types with a low risk of irritation or comedogenicity.


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