Science
Mechanism of Action
This compound acts as a precursor within permanent hair coloring systems, undergoing an oxidative reaction inside the hair fiber with agents like hydrogen peroxide to form colorants. On the skin, its primary mechanism of action involves eliciting potential sensitization and irritation responses.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Related p-Aminophenol exhibits solubility affected by pH and may discolor in alkaline conditions. It is sensitive to air and light, and can decompose when exposed to heat.
Conflicts
- acids
- chloroformates
- strong oxidizing agents
- air
- light
- heat
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed p-, m-, and o-Aminophenols safe for use in hair dyes under specific concentration limits. While detailed data for HYDROXYETHYLAMINOMETHYL-P-AMINOPHENOL itself is limited, a related compound, p-Aminophenol, is typically formulated in oxidative hair dyes at a maximum concentration of 1.8%, resulting in an in-use concentration of approximately 0.9%. The Scientific Committee on Consumer Safety (SCCS) has similarly evaluated other aminophenol derivatives, permitting their use in permanent hair dye formulations up to 2.0% (in-bottle) and 1.0% (in-use), but mandating a warning for sensitization risk. HYDROXYETHYLAMINOMETHYL-P-AMINOPHENOL hydrochloride is specifically classified as a Category 1 skin sensitizer and is harmful if swallowed. Precautions include avoiding use on irritated or sensitive scalps, or in individuals with a history of allergic reactions to hair dyes.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Primarily serving as a hair dye precursor, this ingredient carries a high risk of skin sensitization and irritation, rendering it unsuitable and ill-advised for inclusion in precision skincare formulations.
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References
Sources