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Moumoujus

HYDROXYBENZOMORPHOLINE.

Avoid CAS 26021-57-8 / HAIR DYEING

Hydroxybenzomorpholine is a heterocyclic compound utilized as a permanent hair colorant. Its function is to produce color directly inside the hair fiber, typically through an oxidative process involving hydrogen peroxide. There is no current evidence supporting its use or efficacy in topical skincare applications.

Summary

Colorant

Science

Mechanism of Action

This compound acts as a hair colorant by undergoing reactions within the hair fiber, leading to the formation of permanent color. This complex process requires precise formulation and is generally activated through interaction with hydrogen peroxide.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 No studies demonstrate direct skincare efficacy. Safety assessments for hair dye formulations, conducted by the CIR Expert Panel and SCCNFP/SCCP, indicated safety for use at concentrations up to 2% in formulation (1% on-head when mixed with hydrogen peroxide), noting minimal irritation, no sensitization or photoallergenicity, and non-mutagenicity.

Transparency

Dusting Analysis

Not commonly dusted

Data on 'dusting' behavior for this ingredient is not available.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The kinetics of color formation are influenced by the pH of the dyeing solution and the duration of contact.

Conflicts

  • Nitrosating agents (potential for nitrosamine impurity formation)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel deemed it safe as a hair dye ingredient, affirming it was practically nonirritating to the eye, produced only slight skin irritation, and was neither a sensitizer nor a photoallergen or mutagen. However, the SCCS/SCCP also concluded it was safe in permanent hair dye formulations at a maximum in-use concentration of 1.0% (after mixing), but highlighted that sensitization data did not fully conform to OECD guidelines and recommended a label warning for sensitization risk. The CIR further noted the potential for nitrosamine impurities, advising against its use with nitrosating agents.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Hydroxybenzomorpholine functions exclusively as a hair colorant and lacks documented benefits for skin, making it unsuitable for precision skincare formulations.

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